                         SEQUENCE LISTING

<110>  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
       JAVITCH, Jonathan A
 
<120>  A FUNCTIONAL COMPLEMENTATION ASSAY FOR DEFINED GPCR OLIGOMERS

<130>  IR 2388 (C035795/0232933)

<150>  61/133,714
<151>  2008-07-01

<160>  100   

<170>  PatentIn version 3.3

<210>  1
<211>  2487
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2/D4Long Gqi5

<400>  1
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgcctt ggtttgtata cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct taatgactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaagggcaa ctgtactcac cccgaggaca tgaaactctg caccgttatc    840

atgaagtcta atgggagttt cccagtgaac aggcggagag tggaggctgc ccggcgagcc    900

caggagctgg agatggagat gctctccagc accagcccac ccgagaggac ccggtacagc    960

cccatcccac ccagccacca ccagctgact ctccccgacc cgtcccacca tggtctccac   1020

agcactcccg acagccccgc caaaccagag aagaatgggc atgccaaaga ccaccccaag   1080

attgccaaga tctttgagat ccagaccatg cccaatggca aaacgcgtac ctccctcaag   1140

accatgagcc gtaggaagct ctcccagcag aaggcaaaga aagctcgtca gatgctcgcc   1200

attgttctcg gcgtgttcat catctgctgg ctgcccttct tcatcacaca catcctgaac   1260

atacactgtg actgcaacat cccgcctgtc ctggttagcg ccttcacgtg gctgggctat   1320

gtcaacagcg ccgtgaaccc catcatctac accaccttca acattgagtt ccgcaaggcc   1380

ttcctgaaga tcctccactg tttcgaaatg actctggagt ccatcatggc gtgctgcctg   1440

agcgaggagg ccaaggaagc ccggcggatc aacgacgaga tcgagcggca gctccgcagg   1500

gacaagcggg acgcccgccg ggagctcaag ctgctgctgc tcgggacagg agagagtggc   1560

aagagtacgt ttatcaagca gatgagaatc atccatgggt caggatactc tgatgaagat   1620

aaaaggggct tcaccaagct ggtgtatcag aacatcttca cggccatgca ggccatgatc   1680

agagccatgg acacactcaa gatcccatac aagtatgagc acaataaggc tcatgcacaa   1740

ttagttcgag aagttgatgt ggagaaggtg tctgcttttg agaatccata tgtagatgca   1800

ataaagagtt tatggaatga tcctggaatc caggaatgct atgatagacg acgagaatat   1860

caattatctg actctaccaa atactatctt aatgacttgg accgcgtagc tgaccctgcc   1920

tacctgccta cgcaacaaga tgtgcttaga gttcgagtcc ccaccacagg gatcatcgaa   1980

tacccctttg acttacaaag tgtcattttc agaatggtcg atgtaggggg ccaaaggtca   2040

gagagaagaa aatggataca ctgctttgaa aatgtcacct ctatcatgtt tctagtagcg   2100

cttagtgaat atgatcaagt tctcgtggag tcagacaatg agaaccgaat ggaggaaagc   2160

aaggctctct ttagaacaat tatcacatac ccctggttcc agaactcctc ggttattctg   2220

ttcttaaaca agaaagatct tctagaggag aaaatcatgt attcccatct agtcgactac   2280

ttcccagaat atgatggacc ccagagagat gcccaggcag cccgagaatt cattctgaag   2340

atgttcgtgg acctgaaccc agacagtgac aaaattatct actcccactt cacgtgcgcc   2400

acagacaccg agaatatccg ctttgtcttt gctgccgtca aggacaccat cctccagttg   2460

aacctgaagg atattggtct gttctaa                                       2487


<210>  2
<211>  2487
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2/D4Long/CAM Gqi5

<400>  2
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgcctt ggtttgtata cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct taatgactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaagggcaa ctgtactcac cccgaggaca tgaaactctg caccgttatc    840

atgaagtcta atgggagttt cccagtgaac aggcggagag tggaggctgc ccggcgagcc    900

caggagctgg agatggagat gctctccagc accagcccac ccgagaggac ccggtacagc    960

cccatcccac ccagccacca ccagctgact ctccccgacc cgtcccacca tggtctccac   1020

agcactcccg acagccccgc caaaccagag aagaatgggc atgccaaaga ccaccccaag   1080

attgccaaga tctttgagat ccagaccatg cccaatggca aaacgcgtac ctccctcaag   1140

accatgagcc gtaggaagct ctcccagcag aaggagaaga aagccactca gatgctcgcc   1200

attgttctcg gcgtgttcat catctgctgg ctgcccttct tcatcacaca catcctgaac   1260

atacactgtg actgcaacat cccgcctgtc ctggttagcg ccttcacgtg gctgggctat   1320

gtcaacagcg ccgtgaaccc catcatctac accaccttca acattgagtt ccgcaaggcc   1380

ttcctgaaga tcctccactg tttcgaaatg actctggagt ccatcatggc gtgctgcctg   1440

agcgaggagg ccaaggaagc ccggcggatc aacgacgaga tcgagcggca gctccgcagg   1500

gacaagcggg acgcccgccg ggagctcaag ctgctgctgc tcgggacagg agagagtggc   1560

aagagtacgt ttatcaagca gatgagaatc atccatgggt caggatactc tgatgaagat   1620

aaaaggggct tcaccaagct ggtgtatcag aacatcttca cggccatgca ggccatgatc   1680

agagccatgg acacactcaa gatcccatac aagtatgagc acaataaggc tcatgcacaa   1740

ttagttcgag aagttgatgt ggagaaggtg tctgcttttg agaatccata tgtagatgca   1800

ataaagagtt tatggaatga tcctggaatc caggaatgct atgatagacg acgagaatat   1860

caattatctg actctaccaa atactatctt aatgacttgg accgcgtagc tgaccctgcc   1920

tacctgccta cgcaacaaga tgtgcttaga gttcgagtcc ccaccacagg gatcatcgaa   1980

tacccctttg acttacaaag tgtcattttc agaatggtcg atgtaggggg ccaaaggtca   2040

gagagaagaa aatggataca ctgctttgaa aatgtcacct ctatcatgtt tctagtagcg   2100

cttagtgaat atgatcaagt tctcgtggag tcagacaatg agaaccgaat ggaggaaagc   2160

aaggctctct ttagaacaat tatcacatac ccctggttcc agaactcctc ggttattctg   2220

ttcttaaaca agaaagatct tctagaggag aaaatcatgt attcccatct agtcgactac   2280

ttcccagaat atgatggacc ccagagagat gcccaggcag cccgagaatt cattctgaag   2340

atgttcgtgg acctgaaccc agacagtgac aaaattatct actcccactt cacgtgcgcc   2400

acagacaccg agaatatccg ctttgtcttt gctgccgtca aggacaccat cctccagttg   2460

aacctgaagg atattggtct gttctaa                                       2487


<210>  3
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2/D4short Gqi5

<400>  3
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgcctt ggtttgtata cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct taatgactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctggtta gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  4
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S AAAA(219-222RRKR) Gqi5

<400>  4
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagagcag cagcagcagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  5
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S AAAA(219-222RRKR) /CAM Gqi5

<400>  5
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagagcag cagcagcagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggcaa agaaagctcg tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  6
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S D131A/R132A Gqi5

<400>  6
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgcagcata cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  7
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S CAM (E339A/T343R) Gqi5

<400>  7
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggcaa agaaagctcg tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  8
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S CAM/N393A Gqi5

<400>  8
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggcaa agaaagctcg tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtggc tcccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  9
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S D114A Gqi5

<400>  9
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ctgcggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggccgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  10
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S D114A/CAM Gqi5

<400>  10
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggccgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggcaa agaaagctcg tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  11
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S D80A Gqi5

<400>  11
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg ctctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  12
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S D80A/CAM Gqi5

<400>  12
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg ctctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggcaa agaaagctcg tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  13
<211>  2379
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S delta213-219 Gqi5

<400>  13
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaaaatacg caagcgagtc    720

aacaccaaac gcagcagccg agctttcagg gcccacctga gggctccact aaaggaggct    780

gcccggcgag cccaggagct ggagatggag atgctctcca gcaccagccc acccgagagg    840

acccggtaca gccccatccc acccagccac caccagctga ctctccccga cccgtcccac    900

catggtctcc acagcactcc cgacagcccc gccaaaccag agaagaatgg gcatgccaaa    960

gaccacccca agattgccaa gatctttgag atccagacca tgcccaatgg caaaacgcgt   1020

acctccctca agaccatgag ccgtaggaag ctctcccagc agaaggagaa gaaagccact   1080

cagatgctcg ccattgttct cggcgtgttc atcatctgct ggctgccctt cttcatcaca   1140

cacatcctga acatacactg tgactgcaac atcccgcctg tcctgtacag cgccttcacg   1200

tggctgggct atgtcaacag cgccgtgaac cccatcatct acaccacctt caacattgag   1260

ttccgcaagg ccttcctgaa gatcctccac tgtttcgaaa tgactctgga gtccatcatg   1320

gcgtgctgcc tgagcgagga ggccaaggaa gcccggcgga tcaacgacga gatcgagcgg   1380

cagctccgca gggacaagcg ggacgcccgc cgggagctca agctgctgct gctcgggaca   1440

ggagagagtg gcaagagtac gtttatcaag cagatgagaa tcatccatgg gtcaggatac   1500

tctgatgaag ataaaagggg cttcaccaag ctggtgtatc agaacatctt cacggccatg   1560

caggccatga tcagagccat ggacacactc aagatcccat acaagtatga gcacaataag   1620

gctcatgcac aattagttcg agaagttgat gtggagaagg tgtctgcttt tgagaatcca   1680

tatgtagatg caataaagag tttatggaat gatcctggaa tccaggaatg ctatgataga   1740

cgacgagaat atcaattatc tgactctacc aaatactatc ttaatgactt ggaccgcgta   1800

gctgaccctg cctacctgcc tacgcaacaa gatgtgctta gagttcgagt ccccaccaca   1860

gggatcatcg aatacccctt tgacttacaa agtgtcattt tcagaatggt cgatgtaggg   1920

ggccaaaggt cagagagaag aaaatggata cactgctttg aaaatgtcac ctctatcatg   1980

tttctagtag cgcttagtga atatgatcaa gttctcgtgg agtcagacaa tgagaaccga   2040

atggaggaaa gcaaggctct ctttagaaca attatcacat acccctggtt ccagaactcc   2100

tcggttattc tgttcttaaa caagaaagat cttctagagg agaaaatcat gtattcccat   2160

ctagtcgact acttcccaga atatgatgga ccccagagag atgcccaggc agcccgagaa   2220

ttcattctga agatgttcgt ggacctgaac ccagacagtg acaaaattat ctactcccac   2280

ttcacgtgcg ccacagacac cgagaatatc cgctttgtct ttgctgccgt caaggacacc   2340

atcctccagt tgaacctgaa ggatattggt ctgttctaa                          2379


<210>  14
<211>  2379
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S delta213-219/ CAM Gqi5

<400>  14
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaaaatacg caagcgagtc    720

aacaccaaac gcagcagccg agctttcagg gcccacctga gggctccact aaaggaggct    780

gcccggcgag cccaggagct ggagatggag atgctctcca gcaccagccc acccgagagg    840

acccggtaca gccccatccc acccagccac caccagctga ctctccccga cccgtcccac    900

catggtctcc acagcactcc cgacagcccc gccaaaccag agaagaatgg gcatgccaaa    960

gaccacccca agattgccaa gatctttgag atccagacca tgcccaatgg caaaacgcgt   1020

acctccctca agaccatgag ccgtaggaag ctctcccagc agaaggcaaa gaaagctcgt   1080

cagatgctcg ccattgttct cggcgtgttc atcatctgct ggctgccctt cttcatcaca   1140

cacatcctga acatacactg tgactgcaac atcccgcctg tcctgtacag cgccttcacg   1200

tggctgggct atgtcaacag cgccgtgaac cccatcatct acaccacctt caacattgag   1260

ttccgcaagg ccttcctgaa gatcctccac tgtttcgaaa tgactctgga gtccatcatg   1320

gcgtgctgcc tgagcgagga ggccaaggaa gcccggcgga tcaacgacga gatcgagcgg   1380

cagctccgca gggacaagcg ggacgcccgc cgggagctca agctgctgct gctcgggaca   1440

ggagagagtg gcaagagtac gtttatcaag cagatgagaa tcatccatgg gtcaggatac   1500

tctgatgaag ataaaagggg cttcaccaag ctggtgtatc agaacatctt cacggccatg   1560

caggccatga tcagagccat ggacacactc aagatcccat acaagtatga gcacaataag   1620

gctcatgcac aattagttcg agaagttgat gtggagaagg tgtctgcttt tgagaatcca   1680

tatgtagatg caataaagag tttatggaat gatcctggaa tccaggaatg ctatgataga   1740

cgacgagaat atcaattatc tgactctacc aaatactatc ttaatgactt ggaccgcgta   1800

gctgaccctg cctacctgcc tacgcaacaa gatgtgctta gagttcgagt ccccaccaca   1860

gggatcatcg aatacccctt tgacttacaa agtgtcattt tcagaatggt cgatgtaggg   1920

ggccaaaggt cagagagaag aaaatggata cactgctttg aaaatgtcac ctctatcatg   1980

tttctagtag cgcttagtga atatgatcaa gttctcgtgg agtcagacaa tgagaaccga   2040

atggaggaaa gcaaggctct ctttagaaca attatcacat acccctggtt ccagaactcc   2100

tcggttattc tgttcttaaa caagaaagat cttctagagg agaaaatcat gtattcccat   2160

ctagtcgact acttcccaga atatgatgga ccccagagag atgcccaggc agcccgagaa   2220

ttcattctga agatgttcgt ggacctgaac ccagacagtg acaaaattat ctactcccac   2280

ttcacgtgcg ccacagacac cgagaatatc cgctttgtct ttgctgccgt caaggacacc   2340

atcctccagt tgaacctgaa ggatattggt ctgttctaa                          2379


<210>  15
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S N393A Gqi5

<400>  15
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtggc tcccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  16
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  16
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ctgcggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacgctta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  17
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S R132A/CAM Gqi5

<400>  17
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacgctta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggcaa agaaagctcg tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  18
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S V136D/M140E Gqi5

<400>  18
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgat    480

gccatgcccg aactgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  19
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2S V136D/M140E/CAM Gqi5

<400>  19
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgat    480

gccatgcccg aactgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggcaa agaaagctcg tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  20
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2SAAAA(IYIV212-215)Gqi5

<400>  20
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaaggcagc agcagcactc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  21
<211>  2400
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2SWT Gqi5

<400>  21
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg   1380

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc   1440

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga   1500

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat   1560

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca   1620

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag   1680

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga   1740

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat   1800

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt   1860

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt   1920

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt   1980

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg   2040

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca   2100

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag   2160

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga   2220

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt   2280

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   2340

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   2400


<210>  22
<211>  1407
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2/D4L

<400>  22
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cttggtttgt atacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttaatgac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaaggg caactgtact caccccgagg acatgaaact ctgcaccgtt    840

atcatgaagt ctaatgggag tttcccagtg aacaggcgga gagtggaggc tgcccggcga    900

gcccaggagc tggagatgga gatgctctcc agcaccagcc cacccgagag gacccggtac    960

agccccatcc cacccagcca ccaccagctg actctccccg acccgtccca ccatggtctc   1020

cacagcactc ccgacagccc cgccaaacca gagaagaatg ggcatgccaa agaccacccc   1080

aagattgcca agatctttga gatccagacc atgcccaatg gcaaaacgcg tacctccctc   1140

aagaccatga gccgtaggaa gctctcccag cagaaggaga agaaagccac tcagatgctc   1200

gccattgttc tcggcgtgtt catcatctgc tggctgccct tcttcatcac acacatcctg   1260

aacatacact gtgactgcaa catcccgcct gtcctggtta gcgccttcac gtggctgggc   1320

tatgtcaaca gcgccgtgaa ccccatcatc tacaccacct tcaacattga gttccgcaag   1380

gccttcctga agatcctcca ctgttga                                       1407


<210>  23
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2/D4S

<400>  23
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cttggtttgt atacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttaatgac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgg ttagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  24
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2SWT

<400>  24
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  25
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S AAAA(RRKR219-222)

<400>  25
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagag cagcagcagc agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  26
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D131A/R132A

<400>  26
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgcagc atacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  27
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S CAM

<400>  27
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg caaagaaagc ccgtcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  28
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D114A

<400>  28
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggccgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  29
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D80A

<400>  29
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgctctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgctga   1320


<210>  30
<211>  1299
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S delta213-219

<400>  30
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaaaat acgcaagcga    720

gtcaacacca aacgcagcag ccgagctttc agggcccacc tgagggctcc actaaaggag    780

gctgcccggc gagcccagga gctggagatg gagatgctct ccagcaccag cccacccgag    840

aggacccggt acagccccat cccacccagc caccaccagc tgactctccc cgacccgtcc    900

caccatggtc tccacagcac tcccgacagc cccgccaaac cagagaagaa tgggcatgcc    960

aaagaccacc ccaagattgc caagatcttt gagatccaga ccatgcccaa tggcaaaacg   1020

cgtacctccc tcaagaccat gagccgtagg aagctctccc agcagaagga gaagaaagcc   1080

actcagatgc tcgccattgt tctcggcgtg ttcatcatct gctggctgcc cttcttcatc   1140

acacacatcc tgaacataca ctgtgactgc aacatcccgc ctgtcctgta cagcgccttc   1200

acgtggctgg gctatgtcaa cagcgccgtg aaccccatca tctacaccac cttcaacatt   1260

gagttccgca aggccttcct gaagatcctc cactgttga                          1299


<210>  31
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S N393A

<400>  31
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt ggctcccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  32
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S R132A

<400>  32
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacgc ttacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  33
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S V136D/M140E

<400>  33
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gatgccatgc ccgaactgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  34
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S CAM/N393A

<400>  34
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg caaagaaagc ccgtcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt ggctcccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  35
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D114A/CAM

<400>  35
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggccgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg caaagaaagc ccgtcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  36
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D114A/D131N

<400>  36
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggccgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcaacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  37
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D114A/R132A

<400>  37
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggccgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacgc ttacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  38
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D114A/V136D/M140E

<400>  38
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggccgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gatgccatgc ccgaactgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  39
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S D131N

<400>  39
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcaacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atctacacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  40
<211>  1320
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycD2S Y397F (Y7.53F)

<400>  40
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga gcagaagctg     60

atctccgaag aggacctgga tccactgaat ctgtcctggt atgatgatga tctggagagg    120

cagaactgga gccggccctt caacgggtca gacgggaagg cggacagacc ccactacaac    180

tactatgcca cactgctcac cctgctcatc gctgtcatcg tcttcggcaa cgtgctggtg    240

tgcatggctg tgtcccgcga gaaggcgctg cagaccacca ccaactacct gatcgtcagc    300

ctcgcagtgg ccgacctcct cgtcgccaca ctggtcatgc cctgggttgt ctacctggag    360

gtggtaggtg agtggaaatt cagcaggatt cactgtgaca tcttcgtcac tctggacgtc    420

atgatgtgca cggcgagcat cctgaacttg tgtgccatca gcatcgacag gtacacagct    480

gtggccatgc ccatgctgta caatacgcgc tacagctcca agcgccgggt caccgtcatg    540

atctccatcg tctgggtcct gtccttcacc atctcctgcc cactcctctt cggactcaat    600

aacgcagacc agaacgagtg catcattgcc aacccggcct tcgtggtcta ctcctccatc    660

gtctccttct acgtgccctt cattgtcacc ctgctggtct acatcaagat ctacattgtc    720

ctccgcagac gccgcaagcg agtcaacacc aaacgcagca gccgagcttt cagggcccac    780

ctgagggctc cactaaagga ggctgcccgg cgagcccagg agctggagat ggagatgctc    840

tccagcacca gcccacccga gaggacccgg tacagcccca tcccacccag ccaccaccag    900

ctgactctcc ccgacccgtc ccaccatggt ctccacagca ctcccgacag ccccgccaaa    960

ccagagaaga atgggcatgc caaagaccac cccaagattg ccaagatctt tgagatccag   1020

accatgccca atggcaaaac gcgtacctcc ctcaagacca tgagccgtag gaagctctcc   1080

cagcagaagg agaagaaagc cactcagatg ctcgccattg ttctcggcgt gttcatcatc   1140

tgctggctgc ccttcttcat cacacacatc ctgaacatac actgtgactg caacatcccg   1200

cctgtcctgt acagcgcctt cacgtggctg ggctatgtca acagcgccgt gaaccccatc   1260

atcttcacca ccttcaacat tgagttccgc aaggccttcc tgaagatcct ccactgttga   1320


<210>  41
<211>  1425
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; 3HA-human D1

<400>  41
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgcttac     60

ccatacgatg ttccagatta cgctgatagg actctgaaca cctctgccat ggacgggact    120

gggctggtgg tggagaggga cttctctgtt cgtatcctca ctgcctgttt cctgtcgctg    180

ctcatcctgt ccacgctcct ggggaacacg ctggtctgtg ctgccgttat caggttccga    240

cacctgcggt ccaaggtgac caacttcttt gtcatctcct tggctgtgtc agatctcttg    300

gtggccgtcc tggtcatgcc ctggaaggca gtggctgaga ttgctggctt ctggcccttt    360

gggtccttct gtaacatctg ggtggccttt gacatcatgt gctccactgc atccatcctc    420

aacctctgtg tgatcagcgt ggacaggtat tgggctatct ccagcccttt ccggtatgag    480

agaaagatga cccccaaggc agccttcatc ctgatcagtg tggcatggac cttgtctgta    540

ctcatctcct tcatcccagt gcagctcagc tggcacaagg caaaacccac aagcccctct    600

gatggaaatg ccacttccct ggctgagacc atagacaact gtgactccag cctcagcagg    660

acatatgcca tctcatcctc tgtaataagc ttttacatcc ctgtggccat catgattgtc    720

acctacacca ggatctacag gattgctcag aaacaaatac ggcgcattgc ggccttggag    780

agggcagcag tccacgccaa gaattgccag accaccacag gtaatggaaa gcctgtcgaa    840

tgttctcaac cggaaagttc ttttaagatg tccttcaaaa gagaaactaa agtcctgaag    900

actctgtcgg tgatcatggg tgtgtttgtg tgctgttggc tacctttctt catcttgaac    960

tgcattttgc ccttctgtgg gtctggggag acgcagccct tctgcattga ttccaacacc   1020

tttgacgtgt ttgtgtggtt tgggtgggct aattcatcct tgaaccccat catttatgcc   1080

tttaatgctg attttcggaa ggcattttca accctcttag gatgctacag actttgccct   1140

gcgacgaata atgccataga gacggtgagt atcaataaca atggggccgc gatgttttcc   1200

agccatcatg agccacgagg ctccatctcc aaggagtgca atctggttta cctgatccca   1260

catgctgtgg gctcctctga ggacctgaaa aaggaggagg cagctggcat cgccagaccc   1320

ttggagaagc tgtccccagc cctatcggtc atattggact atgacactga cgtctctctg   1380

gagaagatcc aacccatcac acaaaacggt cagcacccaa cctga                   1425


<210>  42
<211>  2526
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; 3HAD1-linker-Gqi5

<400>  42
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgcttac     60

ccatacgatg ttccagatta cgctgatagg actctgaaca cctctgccat ggacgggact    120

gggctggtgg tggagaggga cttctctgtt cgtatcctca ctgcctgttt cctgtcgctg    180

ctcatcctgt ccacgctcct ggggaacacg ctggtctgtg ctgccgttat caggttccga    240

cacctgcggt ccaaggtgac caacttcttt gtcatctcct tggctgtgtc agatctcttg    300

gtggccgtcc tggtcatgcc ctggaaggca gtggctgaga ttgctggctt ctggcccttt    360

gggtccttct gtaacatctg ggtggccttt gacatcatgt gctccactgc atccatcctc    420

aacctctgtg tgatcagcgt ggacaggtat tgggctatct ccagcccttt ccggtatgag    480

agaaagatga cccccaaggc agccttcatc ctgatcagtg tggcatggac cttgtctgta    540

ctcatctcct tcatcccagt gcagctcagc tggcacaagg caaaacccac aagcccctct    600

gatggaaatg ccacttccct ggctgagacc atagacaact gtgactccag cctcagcagg    660

acatatgcca tctcatcctc tgtaataagc ttttacatcc ctgtggccat catgattgtc    720

acctacacca ggatctacag gattgctcag aaacaaatac ggcgcattgc ggccttggag    780

agggcagcag tccacgccaa gaattgccag accaccacag gtaatggaaa gcctgtcgaa    840

tgttctcaac cggaaagttc ttttaagatg tccttcaaaa gagaaactaa agtcctgaag    900

actctgtcgg tgatcatggg tgtgtttgtg tgctgttggc tacctttctt catcttgaac    960

tgcattttgc ccttctgtgg gtctggggag acgcagccct tctgcattga ttccaacacc   1020

tttgacgtgt ttgtgtggtt tgggtgggct aattcatcct tgaaccccat catttatgcc   1080

tttaatgctg attttcggaa ggcattttca accctcttag gatgctacag actttgccct   1140

gcgacgaata atgccataga gacggtgagt atcaataaca atggggccgc gatgttttcc   1200

agccatcatg agccacgagg ctccatctcc aaggagtgca atctggttta cctgatccca   1260

catgctgtgg gctcctctga ggacctgaaa aaggaggagg cagctggcat cgccagaccc   1320

ttggagaagc tgtccccagc cctatcggtc atattggact atgacactga cgtctctctg   1380

gagaagatcc aacccatcac acaaaacggt cagcacccaa ccttcgaaag acctgcagac   1440

ggtagaatga ctctggagtc catcatggcg tgctgcctga gcgaggaggc caaggaagcc   1500

cggcggatca acgacgagat cgagcggcag ctccgcaggg acaagcggga cgcccgccgg   1560

gagctcaagc tgctgctgct cgggacagga gagagtggca agagtacgtt tatcaagcag   1620

atgagaatca tccatgggtc aggatactct gatgaagata aaaggggctt caccaagctg   1680

gtgtatcaga acatcttcac ggccatgcag gccatgatca gagccatgga cacactcaag   1740

atcccataca agtatgagca caataaggct catgcacaat tagttcgaga agttgatgtg   1800

gagaaggtgt ctgcttttga gaatccatat gtagatgcaa taaagagttt atggaatgat   1860

cctggaatcc aggaatgcta tgatagacga cgagaatatc aattatctga ctctaccaaa   1920

tactatctta atgacttgga ccgcgtagct gaccctgcct acctgcctac gcaacaagat   1980

gtgcttagag ttcgagtccc caccacaggg atcatcgaat acccctttga cttacaaagt   2040

gtcattttca gaatggtcga tgtagggggc caaaggtcag agagaagaaa atggatacac   2100

tgctttgaaa atgtcacctc tatcatgttt ctagtagcgc ttagtgaata tgatcaagtt   2160

ctcgtggagt cagacaatga gaaccgaatg gaggaaagca aggctctctt tagaacaatt   2220

atcacatacc cctggttcca gaactcctcg gttattctgt tcttaaacaa gaaagatctt   2280

ctagaggaga aaatcatgta ttcccatcta gtcgactact tcccagaata tgatggaccc   2340

cagagagatg cccaggcagc ccgagaattc attctgaaga tgttcgtgga cctgaaccca   2400

gacagtgaca aaattatcta ctcccacttc acgtgcgcca cagacaccga gaatatccgc   2460

tttgtctttg ctgccgtcaa ggacaccatc ctccagttga acctgaagga tattggtctg   2520

ttctaa                                                              2526


<210>  43
<211>  1257
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; 3HA-human 5HT1b

<400>  43
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgcttac     60

ccatacgatg ttccagatta cgctgatgag gaaccgggtg ctcagtgcgc tccaccgccg    120

cccgcgggct ccgagacctg ggttcctcaa gccaacttat cctctgctcc ctcccaaaac    180

tgcagcgcca aggactacat ttaccaggac tccatctccc taccctggaa agtactgctg    240

gttatgctat tggcgctcat caccttggcc accacgctct ccaatgcctt tgtgattgcc    300

acagtgtacc ggacccggaa actgcacacc ccggctaact acctgatcgc ctctctggcg    360

gtcaccgacc tgcttgtgtc catcctggtg atgcccatca gcaccatgta cactgtcacc    420

ggccgctgga cactgggcca ggtggtctgt gacttctggc tgtcgtcgga catcacttgt    480

tgcactgcct ccatcctgca cctctgtgtc atcgccctgg accgctactg ggccatcacg    540

gacgccgtgg agtactcagc taaaaggact cccaagaggg cggcggtcat gatcgcgctg    600

gtgtgggtct tctccatctc tatctcgctg ccgcccttct tctggcgtca ggctaaggcc    660

gaagaggagg tgtcggaatg cgtggtgaac accgaccaca tcctctacac ggtctactcc    720

acggtgggtg ctttctactt ccccaccctg ctcctcatcg ccctctatgg ccgcatctac    780

gtagaagccc gctcccggat tttgaaacag acgcccaaca ggaccggcaa gcgcttgacc    840

cgagcccagc tgataaccga ctcccccggg tccacgtcct cggtcacctc tattaactcg    900

cgggttcccg acgtgcccag cgaatccgga tctcctgtgt atgtgaacca agtcaaagtg    960

cgagtctccg acgccctgct ggaaaagaag aaactcatgg ccgctaggga gcgcaaagcc   1020

accaagaccc tagggatcat tttgggagcc tttattgtgt gttggctacc cttcttcatc   1080

atctccctag tgatgcctat ctgcaaagat gcctgctggt tccacctagc catctttgac   1140

ttcttcacat ggctgggcta tctcaactcc ctcatcaacc ccataatcta taccatgtcc   1200

aatgaggact ttaaacaagc attccataaa ctgatacgtt ttaagtgcac aagttga      1257


<210>  44
<211>  1326
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; 3HA-human A2a

<400>  44
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgcttac     60

ccatacgatg ttccagatta cgctgatatc cccatcatgg gctcctcggt gtacatcacg    120

gtggagctgg ccattgctgt gctggccatc ctgggcaatg tgctggtgtg ctgggccgtg    180

tggctcaaca gcaacctgca gaacgtcacc aactactttg tggtgtcact ggcggcggcc    240

gacatcgcag tgggtgtgct cgccatcccc tttgccatca ccatcagcac cgggttctgc    300

gctgcctgcc acggctgcct cttcattgcc tgcttcgtcc tggtcctcac gcagagctcc    360

atcttcagtc tcctggccat cgccattgac cgctacattg ccatccgcat cccgctccgg    420

tacaatggct tggtgaccgg cacgagggct aagggcatca ttgccatctg ctgggtgctg    480

tcgtttgcca tcggcctgac tcccatgcta ggttggaaca actgcggtca gccaaaggag    540

ggcaagaacc actcccaggg ctgcggggag ggccaagtgg cctgtctctt tgaggatgtg    600

gtccccatga actacatggt gtacttcaac ttctttgcct gtgtgctggt gcccctgctg    660

ctcatgctgg gtgtctattt gcggatcttc ctggcggcgc gacgacagct gaagcagatg    720

gagagccagc ctctgccggg ggagcgggca cggtccacac tgcagaagga ggtccatgct    780

gccaagtcac tggccatcat tgtggggctc tttgccctct gctggctgcc cctacacatc    840

atcaactgct tcactttctt ctgccccgac tgcagccacg cccctctctg gctcatgtac    900

ctggccatcg tcctctccca caccaattcg gttgtgaatc ccttcatcta cgcctaccgt    960

atccgcgagt tccgccagac cttccgcaag atcattcgca gccacgtcct gaggcagcaa   1020

gaacctttca aggcagctgg caccagtgcc cgggtcttgg cagctcatgg cagtgacgga   1080

gagcaggtca gcctccgtct caacggccac ccgccaggag tgtgggccaa cggcagtgct   1140

ccccaccctg agcggaggcc caatggctac gccctggggc tggtgagtgg agggagtgcc   1200

caagagtccc aggggaacac gggcctccca gacgtggagc tccttagcca tgagctcaag   1260

ggagtgtgcc cagagccccc tggcctagat gaccccctgg cccaggatgg agcaggagtg   1320

tcctga                                                              1326


<210>  45
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; 3HA-human CB1

<400>  45
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgcttac     60

ccatacgatg ttccagatta cgctgataag tcgatcctag atggccttgc agataccacc    120

ttccgcacca tcaccactga cctcctgtac gtgggctcaa atgacattca gtacgaagac    180

atcaaaggtg acatggcatc caaattaggg tacttcccac agaaattccc tttaacttcc    240

tttaggggaa gtcccttcca agagaagatg actgcgggag acaaccccca gctagtccca    300

gcagaccagg tgaacattac agaattttac aacaagtctc tctcgtcctt caaggagaat    360

gaggagaaca tccagtgtgg ggagaacttc atggacatag agtgtttcat ggtcctgaac    420

cccagccagc agctggccat tgcagtcctg tccctcacgc tgggcacctt cacggtcctg    480

gagaacctcc tggtgctgtg cgtcatcctc cactcccgca gcctccgctg caggccttcc    540

taccacttca tcggcagcct ggcggtggca gacctcctgg ggagtgtcat ttttgtctac    600

agcttcattg acttccacgt gttccaccgc aaagatagcc gcaacgtgtt tctgttcaaa    660

ctgggtgggg tcacggcctc cttcactgcc tccgtgggca gcctgttcct cacagccatc    720

gacaggtaca tatccattca caggcccctg gcctataaga ggattgtcac caggcccaag    780

gccgtggtgg cgttttgcct gatgtggacc atagccattg tgatcgccgt gctgcctctc    840

ctgggctgga actgcgagaa actgcaatct gtttgctcag acattttccc acacattgat    900

gaaacctacc tgatgttctg gatcggggtc accagcgtac tgcttctgtt catcgtgtat    960

gcgtacatgt atattctctg gaaggctcac agccacgccg tccgcatgat tcagcgtggc   1020

acccagaaga gcatcatcat ccacacgtct gaggatggga aggtacaggt gacccggcca   1080

gaccaagccc gcatggacat taggttagcc aagaccctgg tcctgatcct ggtggtgttg   1140

atcatctgct ggggccctct gcttgcaatc atggtgtatg atgtctttgg gaagatgaac   1200

aagctcatta agacggtgtt tgcattctgc agtatgctct gcctgctgaa ctccaccgtg   1260

aaccccatca tctatgctct gaggagtaag gacctgcgac acgctttccg gagcatgttt   1320

ccctcttgtg aaggcactgc gcagcctctg gataacagca tgggggactc ggactgcctg   1380

cacaaacacg caaacaatgc agccagtgtt cacagggccg cagaaagctg catcaagagc   1440

acggtcaaga ttgccaaggt aaccatgtct gtgtccacag acacgtctgc agaggctctg   1500

tga                                                                 1503


<210>  46
<211>  3600
<212>  DNA
<213>  Rattus rattus

<400>  46
atggtccggc tcctcttgat tttcttccca atgatctttt tggagatgtc cattttgccc     60

aggatgcctg acagaaaagt attgctggca ggtgcctcgt cccagcgctc cgtggcgaga    120

atggacggag atgtcatcat cggagccctc ttctcagtcc atcaccagcc tccagccgag    180

aaggtacccg aaaggaagtg tggggagatc agggaacagt atggtatcca gagggtggag    240

gccatgttcc acacgttgga taagattaac gcggacccgg tgctcctgcc caacatcact    300

ctgggcagtg agatccggga ctcctgctgg cactcttcag tggctctcga acagagcatc    360

gaattcatca gagactccct gatttccatc cgagatgaga aggatgggct gaaccgatgc    420

ctgcctgatg gccagaccct gccccctggc aggactaaga agcctattgc tggagtgatc    480

ggccctggct ccagctctgt ggccattcaa gtccagaatc ttctccagct gttcgacatc    540

ccacagatcg cctattctgc cacaagcata gacctgagtg acaaaacttt gtacaaatac    600

ttcctgaggg tggtcccttc tgacactttg caggcaaggg cgatgctcga catagtcaag    660

cgttacaact ggacctatgt ctcagcagtc cacacagaag ggaattacgg cgagagtgga    720

atggatgctt tcaaagaact ggctgcccag gaaggcctct gcatcgcaca ctcggacaaa    780

atctacagca atgctggcga gaagagcttt gaccggctcc tgcgtaaact ccgggagcgg    840

cttcccaagg ccagggttgt ggtctgcttc tgcgagggca tgacagtgcg gggcttactg    900

agtgccatgc gccgcctggg cgtcgtgggc gagttctcac tcattggaag tgatggatgg    960

gcagacagag atgaagtcat cgaaggctat gaggtggaag ccaacggagg gatcacaata   1020

aagcttcagt ctccagaggt caggtcattt gatgactact tcctgaagct gaggctggac   1080

accaacacaa ggaatccttg gttccctgag ttctggcaac atcgcttcca gtgtcgccta   1140

cctggacacc tcttggaaaa ccccaacttt aagaaagtgt gcacaggaaa tgaaagcttg   1200

gaagaaaact atgtccagga cagcaaaatg ggatttgtca tcaatgccat ctatgccatg   1260

gcacatgggc tgcagaacat gcaccatgct ctgtgtcccg gccatgtggg cctgtgtgat   1320

gctatgaaac ccattgatgg caggaagctc ctggatttcc tcatcaaatc ctcttttgtc   1380

ggagtgtctg gagaggaggt gtggttcgat gagaaggggg atgctcccgg aaggtatgac   1440

attatgaatc tgcagtacac agaagctaat cgctatgact atgtccacgt ggggacctgg   1500

catgaaggag tgctgaatat tgatgattac aaaatccaga tgaacaaaag cggaatggta   1560

cgatctgtgt gcagtgagcc ttgcttaaag ggtcagatta aggtcatacg gaaaggagaa   1620

gtgagctgct gctggatctg cacggcctgc aaagagaatg agtttgtgca ggacgagttc   1680

acctgcagag cctgtgacct ggggtggtgg cccaacgcag agctcacagg ctgtgagccc   1740

attcctgtcc gttatcttga gtggagtgac atagaatcta tcatagccat cgccttttct   1800

tgcctgggca tcctcgtgac gctgtttgtc accctcatct tcgttctgta ccgggacaca   1860

cccgtggtca aatcctccag tagggagctc tgctatatca ttctggctgg tattttcctc   1920

ggctatgtgt gccctttcac cctcatcgcc aaacctacta ccacatcctg ctacctccag   1980

cgcctcctag ttggcctctc ttctgccatg tgctactctg ctttagtgac caaaaccaat   2040

cgtattgcac gcatcctggc tggcagcaag aagaagatct gcacccggaa gcccagattc   2100

atgagcgctt gggcccaagt gatcatagcc tccattctga ttagtgtaca gctaacacta   2160

gtggtgacct tgatcatcat ggagcctccc atgcccattt tgtcctaccc gagtatcaag   2220

gaagtctacc ttatctgcaa taccagcaac ctgggtgtag tggcccctgt gggttacaat   2280

ggactcctca tcatgagctg tacctactat gccttcaaga cccgcaacgt gccggccaac   2340

ttcaatgagg ctaaatacat cgccttcacc atgtacacta cctgcatcat ctggctggct   2400

ttcgttccca tttactttgg gagcaactac aagatcatca ctacctgctt cgcggtgagc   2460

ctcagtgtga cggtggccct ggggtgcatg tttactccga agatgtacat catcattgcc   2520

aaacctgaga ggaacgtccg cagtgccttc acgacctctg atgttgtccg catgcacgtc   2580

ggtgatggca aactgccgtg ccgctccaac accttcctca acattttccg gagaaagaag   2640

cccggggcag ggaatgccaa ttctaacggc aagtctgtgt catggtctga accaggtgga   2700

agacaggcgc ccaagggaca gcacgtgtgg cagcgcctct ctgtgcacgt gaagaccaac   2760

gagacggcct gtaaccaaac agccgtaatc aaacccctca ctaaaagtta ccaaggctct   2820

ggcaagagcc tgaccttttc agatgccagc accaagaccc tttacaatgt ggaagaagag   2880

gacaataccc cttctgctca cttcagccct cccagcagcc cttctatggt ggtgcaccga   2940

cgcgggccac ccgtggccac cacaccacct ctgccacccc atctgaccgc agaagagacc   3000

cccctgttcc tggctgattc cgtcatcccc aagggcttgc ctcctcctct cccgcagcag   3060

cagccacagc agccgccccc tcagcagccc ccgcagcagc ccaagtccct gatggaccag   3120

ctgcaaggcg tagtcaccaa cttcggttcg gggattccag atttccatgc ggtgctggca   3180

ggcccgggga caccaggaaa cagcctgcgc tctctgtacc cgcccccgcc tccgccgcaa   3240

cacctgcaga tgctgcccct gcacctgagc accttccagg aggagtccat ctcccctcct   3300

ggggaggaca tcgatgatga cagtgagaga ttcaagctcc tgcaggagtt cgtgtacgag   3360

cgcgaaggga acaccgaaga agatgaattg gaagaggagg aggacctgcc cacagccagc   3420

aagctgaccc ctgaggattc tcctgccctg acgcctcctt ctcctttccg agattccgtg   3480

gcctctggca gctcagtgcc cagttccccc gtatctgagt cggtcctctg cacccctcca   3540

aatgtaacct acgcctctgt cattctgagg gactacaagc aaagctcttc caccctgtag   3600


<210>  47
<211>  3516
<212>  DNA
<213>  Rattus rattus

<400>  47
atggtccttc tgttgatcct gtcagtccta cttctgaaag aagatgtacg agggagtgca     60

cagtccagtg agaggagggt ggtggctcac atgccaggtg acatcattat tggagctctc    120

ttctctgtcc accaccaacc aactgtggac aaagttcatg agaggaagtg tggtgcagtt    180

cgtgagcaat atgggattca gagagtggag gccatgctgc ataccttgga aaggatcaac    240

tcagatccca cactcttgcc caacatcaca cttggctgtg agatcagaga ttcctgctgg    300

cattccgctg tggccctaga acaaagcatt gagtttataa gggattccct catctcttca    360

gaagaggagg aaggtttggt acgctgtgta gatggatctt cttccttccg ctccaagaaa    420

cccatagtgg gagtcattgg gcctggctcg agttctgtgg ccattcaagt ccagaactta    480

ctccagcttt tcaacatacc acagattgct tactctgcaa ccagcatgga tttgagtgac    540

aagactctat tcaagtactt catgagggtt gtaccttccg atgcccagca agctcgagcc    600

atggtagaca tagtgaagag atacaactgg acttatgtct cagctgtgca cacagaaggc    660

aactatggag aaagtgggat ggaggctttc aaagatatgt cagcgaagga agggatttgc    720

atcgcccact cttacaaaat ttacagcaat gctggggaac agagctttga caagctgttg    780

aaaaaactca gaagtcattt acctaaagcc cgggtggtag cttgcttctg tgaaggcatg    840

acagttcgag gtctgctcat ggccatgaga cgcttaggtc tagcagggga gtttctactt    900

ctgggcagtg atggctgggc cgacaggtat gacgtgacag atggatatca gcgagaagct    960

gtcggtggaa ttacaatcaa gcttcagtct cctgatgtca agtggtttga tgattattat   1020

ctgaaactcc ggccagaaac aaacctcaga aacccttggt ttcaagaatt ttggcagcat   1080

cgttttcagt gccggctgga agggtttgca caggagaaca gcaagtacaa caagacttgc   1140

aacagttctc tgactctgag aacacatcat gttcaagatt ccaaaatggg atttgtgata   1200

aatgcaatct attctatggc ttatggactc cacaatatgc agatgtccct gtgtccaggc   1260

tatgcaggcc tctgtgatgc gatgaagcca attgatggac ggaaactttt ggattccctg   1320

atgaaaacca attttactgg agtttctgga gatatgatcc tgtttgatga aaatggagac   1380

tctccaggaa ggtatgaaat aatgaatttc aaggaaatgg gaaaagatta ttttgattac   1440

atcaatgttg gaagttggga caatggggaa ttaaaaatgg atgatgacga agtgtggtcc   1500

aagaaaaata acatcatcag atctgtgtgc agtgaaccat gtgagaaagg ccaaataaag   1560

gtgatccgga agggagaagt cagctgttgt tggacctgca caccttgtaa agagaatgag   1620

tatgtgtttg atgagtacac ctgcaaggca tgccaactgg gctcctggcc cactgacgac   1680

ctgacaggct gtgacttgat cccagtccag tatcttcgct ggggtgaccc tgagccgatt   1740

gcagctgtgg tgtttgcctg cctcggtctg ctagccacct tattcgttac tgtaatcttc   1800

atcatttatc gggacactcc ggtggtcaag tcctccagca gggagctctg ctacattatc   1860

cttgctggca tctgcctggg atacttatgt accttttgcc tcattgcaaa gcccaagcag   1920

atttactgct atcttcagag aattggcatt ggactctctc cagccatgag ctactcagcc   1980

cttgtaacca agaccaaccg tattgcaagg attctagctg gaagcaagaa gaaaatctgt   2040

accaagaagc ccagattcat gagcgcctgt gctcagttag tgatcgcttt cattctcatc   2100

tgtattcagc tgggcattat cgtggccctc tttatcatgg agcctccgga tataatgcat   2160

gactatccaa gcatccgaga agtctacttg atttgtaaca ccaccaacct aggggttgtt   2220

actcctcttg gatacaatgg attattgatt ttgagttgca cgttctatgc gtttaagacc   2280

agaaatgttc cagccaactt taatgaggcc aaatatattg ctttcaccat gtacacaacc   2340

tgcatcatat ggctggcctt cgtgcctatc tactttggca gcaactacaa aatcatcacc   2400

atgtgttttt cagtcagcct cagtgccaca gtggccctgg gttgcatgtt tgtcccgaag   2460

gtgtacatca tcctagccaa accggagaga aatgtgcgca gcgccttcac aacctctaca   2520

gtggtacgca tgcatgtagg agacggcaaa tcatcgtccg ctgccagcag atccagcagc   2580

ctagtcaacc tgtggaagag gaggggctcc tctggggaaa ccctaagctc caacggaaaa   2640

tctgtgactt gggcccagaa tgagaagagt acccgggggc aacatttgtg gcagcgactg   2700

tctgtccaca tcaacaagaa ggagaacccc aaccaaacgg cggtcatcaa accctttccc   2760

aagagcacag agaaccgggg gcctggtgca gcggcaggtg gtggctcggg tcccggtgta   2820

gctggtgctg gtaacgcagg atgcacagca acaggtggcc cggagccacc ggacgccggt   2880

cccaaagcgc tttatgatgt ggcggaggca gaggagagct tccccgcggc tgccaggccg   2940

cgctcgccat cgcccatcag cacgttgagc cacctcgcag gctcggcggg ccgcacagat   3000

gatgatgcgc cgtcgctgca ctctgagaca gctgctcgca gcagctcgtc ccagggctcg   3060

ctcatggagc agatcagcag cgtagtgacg cgcttcacag ccaacatctc cgagctcaac   3120

tccatgatgt tgtccaccgc ggccacgccg gggccccctg gtactccaat ctgctcctcc   3180

tacctgatcc ccaaagagat tcagctgccc acgaccatga cgaccttcgc agagatccag   3240

ccgctgccgg ccatcgaggt gaccggagga gctcaggggg cgacaggcgt atcacctgcc   3300

caggagacgc ccacaggagc tgaatccgcc ccgggcaaac cagatctgga ggagcttgtg   3360

gccctcactc caccatcgcc cttcagggac tcggtggact cggggagcac caccccaaac   3420

tctccagtct cagaatcggc cctctgcatc ccatcctctc ccaaatatga cactctcatc   3480

atcagagatt acacgcagag ttcttcatcg ttgtga                             3516


<210>  48
<211>  1275
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SF-human D3

<400>  48
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggcatc tctgagtcag ctgagtagcc acctgaacta cacctgtggg    120

gcagagaact ccacaggtgc cagccaggcc cgcccacatg cctactatgc cctctcctac    180

tgcgcgctca tcctggccat cgtcttcggc aatggcctgg tgtgcatggc tgtgctgaag    240

gagcgggccc tgcagactac caccaactac ttagtagtga gcctggctgt ggcagacttg    300

ctggtggcca ccttggtgat gccctgggtg gtatacctgg aggtgacagg tggagtctgg    360

aatttcagcc gcatttgctg tgatgttttt gtcaccctgg atgtcatgat gtgtacagcc    420

agcatcctta atctctgtgc catcagcata gacaggtaca ctgcagtggt catgcccgtt    480

cactaccagc atggcacggg acagagctcc tgtcggcgcg tggccctcat gatcacggcc    540

gtctgggtac tggcctttgc tgtgtcctgc cctcttctgt ttggctttaa taccacaggg    600

gaccccactg tctgctccat ctccaaccct gattttgtca tctactcttc agtggtgtcc    660

ttctacctgc cctttggagt gactgtcctt gtctatgcca gaatctatgt ggtgctgaaa    720

caaaggagac ggaaaaggat cctcactcga cagaacagtc agtgcaacag tgtcaggcct    780

ggcttccccc aacaaaccct ctctcctgac ccggcacatc tggagctgaa gcgttactac    840

agcatctgcc aggacactgc cttgggtgga ccaggcttcc aagaaagagg aggagagttg    900

aaaagagagg agaagactcg gaattccctg agtcccacca tagcgcccaa gctcagctta    960

gaagttcgaa aactcagcaa tggcagatta tcgacatctt tgaagctggg gcccctgcaa   1020

cctcggggag tgccacttcg ggagaagaag gcaacccaaa tggtggccat tgtgcttggg   1080

gccttcattg tctgctggct gcccttcttc ttgacccatg ttctcaatac ccactgccag   1140

acatgccacg tgtccccaga gctttacagt gccacgacat ggctgggcta cgtgaatagc   1200

gccctcaacc ctgtgatcta taccaccttc aatatcgagt tccggaaagc cttcctcaag   1260

atcctgtctt gctga                                                    1275


<210>  49
<211>  2358
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD3Gqi5

<400>  49
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggcatc tctgagtcag ctgagtagcc acctgaacta cacctgtggg    120

gcagagaact ccacaggtgc cagccaggcc cgcccacatg cctactatgc cctctcctac    180

tgcgcgctca tcctggccat cgtcttcggc aatggcctgg tgtgcatggc tgtgctgaag    240

gagcgggccc tgcagactac caccaactac ttagtagtga gcctggctgt ggcagacttg    300

ctggtggcca ccttggtgat gccctgggtg gtatacctgg aggtgacagg tggagtctgg    360

aatttcagcc gcatttgctg tgatgttttt gtcaccctgg atgtcatgat gtgtacagcc    420

agcatcctta atctctgtgc catcagcata gacaggtaca ctgcagtggt catgcccgtt    480

cactaccagc atggcacggg acagagctcc tgtcggcgcg tggccctcat gatcacggcc    540

gtctgggtac tggcctttgc tgtgtcctgc cctcttctgt ttggctttaa taccacaggg    600

gaccccactg tctgctccat ctccaaccct gattttgtca tctactcttc agtggtgtcc    660

ttctacctgc cctttggagt gactgtcctt gtctatgcca gaatctatgt ggtgctgaaa    720

caaaggagac ggaaaaggat cctcactcga cagaacagtc agtgcaacag tgtcaggcct    780

ggcttccccc aacaaaccct ctctcctgac ccggcacatc tggagctgaa gcgttactac    840

agcatctgcc aggacactgc cttgggtgga ccaggcttcc aagaaagagg aggagagttg    900

aaaagagagg agaagactcg gaattccctg agtcccacca tagcgcccaa gctcagctta    960

gaagttcgaa aactcagcaa tggcagatta tcgacatctt tgaagctggg gcccctgcaa   1020

cctcggggag tgccacttcg ggagaagaag gcaacccaaa tggtggccat tgtgcttggg   1080

gccttcattg tctgctggct gcccttcttc ttgacccatg ttctcaatac ccactgccag   1140

acatgccacg tgtccccaga gctttacagt gccacgacat ggctgggcta cgtgaatagc   1200

gccctcaacc ctgtgatcta taccaccttc aatatcgagt tccggaaagc cttcctcaag   1260

atcctgtctt gcttcgaaat gactctggag tccatcatgg cgtgctgcct gagcgaggag   1320

gccaaggaag cccggcggat caacgacgag atcgagcggc agctccgcag ggacaagcgg   1380

gacgcccgcc gggagctcaa gctgctgctg ctcgggacag gagagagtgg caagagtacg   1440

tttatcaagc agatgagaat catccatggg tcaggatact ctgatgaaga taaaaggggc   1500

ttcaccaagc tggtgtatca gaacatcttc acggccatgc aggccatgat cagagccatg   1560

gacacactca agatcccata caagtatgag cacaataagg ctcatgcaca attagttcga   1620

gaagttgatg tggagaaggt gtctgctttt gagaatccat atgtagatgc aataaagagt   1680

ttatggaatg atcctggaat ccaggaatgc tatgatagac gacgagaata tcaattatct   1740

gactctacca aatactatct taatgacttg gaccgcgtag ctgaccctgc ctacctgcct   1800

acgcaacaag atgtgcttag agttcgagtc cccaccacag ggatcatcga ataccccttt   1860

gacttacaaa gtgtcatttt cagaatggtc gatgtagggg gccaaaggtc agagagaaga   1920

aaatggatac actgctttga aaatgtcacc tctatcatgt ttctagtagc gcttagtgaa   1980

tatgatcaag ttctcgtgga gtcagacaat gagaaccgaa tggaggaaag caaggctctc   2040

tttagaacaa ttatcacata cccctggttc cagaactcct cggttattct gttcttaaac   2100

aagaaagatc ttctagagga gaaaatcatg tattcccatc tagtcgacta cttcccagaa   2160

tatgatggac cccagagaga tgcccaggca gcccgagaat tcattctgaa gatgttcgtg   2220

gacctgaacc cagacagtga caaaattatc tactcccact tcacgtgcgc cacagacacc   2280

gagaatatcc gctttgtctt tgctgccgtc aaggacacca tcctccagtt gaacctgaag   2340

gatattggtc tgttctaa                                                 2358


<210>  50
<211>  2376
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD3-linker-Gqi5

<400>  50
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggcatc tctgagtcag ctgagtagcc acctgaacta cacctgtggg    120

gcagagaact ccacaggtgc cagccaggcc cgcccacatg cctactatgc cctctcctac    180

tgcgcgctca tcctggccat cgtcttcggc aatggcctgg tgtgcatggc tgtgctgaag    240

gagcgggccc tgcagactac caccaactac ttagtagtga gcctggctgt ggcagacttg    300

ctggtggcca ccttggtgat gccctgggtg gtatacctgg aggtgacagg tggagtctgg    360

aatttcagcc gcatttgctg tgatgttttt gtcaccctgg atgtcatgat gtgtacagcc    420

agcatcctta atctctgtgc catcagcata gacaggtaca ctgcagtggt catgcccgtt    480

cactaccagc atggcacggg acagagctcc tgtcggcgcg tggccctcat gatcacggcc    540

gtctgggtac tggcctttgc tgtgtcctgc cctcttctgt ttggctttaa taccacaggg    600

gaccccactg tctgctccat ctccaaccct gattttgtca tctactcttc agtggtgtcc    660

ttctacctgc cctttggagt gactgtcctt gtctatgcca gaatctatgt ggtgctgaaa    720

caaaggagac ggaaaaggat cctcactcga cagaacagtc agtgcaacag tgtcaggcct    780

ggcttccccc aacaaaccct ctctcctgac ccggcacatc tggagctgaa gcgttactac    840

agcatctgcc aggacactgc cttgggtgga ccaggcttcc aagaaagagg aggagagttg    900

aaaagagagg agaagactcg gaattccctg agtcccacca tagcgcccaa gctcagctta    960

gaagttcgaa aactcagcaa tggcagatta tcgacatctt tgaagctggg gcccctgcaa   1020

cctcggggag tgccacttcg ggagaagaag gcaacccaaa tggtggccat tgtgcttggg   1080

gccttcattg tctgctggct gcccttcttc ttgacccatg ttctcaatac ccactgccag   1140

acatgccacg tgtccccaga gctttacagt gccacgacat ggctgggcta cgtgaatagc   1200

gccctcaacc ctgtgatcta taccaccttc aatatcgagt tccggaaagc cttcctcaag   1260

atcctgtctt gcttcgaaag acctgcagac ggtagaatga ctctggagtc catcatggcg   1320

tgctgcctga gcgaggaggc caaggaagcc cggcggatca acgacgagat cgagcggcag   1380

ctccgcaggg acaagcggga cgcccgccgg gagctcaagc tgctgctgct cgggacagga   1440

gagagtggca agagtacgtt tatcaagcag atgagaatca tccatgggtc aggatactct   1500

gatgaagata aaaggggctt caccaagctg gtgtatcaga acatcttcac ggccatgcag   1560

gccatgatca gagccatgga cacactcaag atcccataca agtatgagca caataaggct   1620

catgcacaat tagttcgaga agttgatgtg gagaaggtgt ctgcttttga gaatccatat   1680

gtagatgcaa taaagagttt atggaatgat cctggaatcc aggaatgcta tgatagacga   1740

cgagaatatc aattatctga ctctaccaaa tactatctta atgacttgga ccgcgtagct   1800

gaccctgcct acctgcctac gcaacaagat gtgcttagag ttcgagtccc caccacaggg   1860

atcatcgaat acccctttga cttacaaagt gtcattttca gaatggtcga tgtagggggc   1920

caaaggtcag agagaagaaa atggatacac tgctttgaaa atgtcacctc tatcatgttt   1980

ctagtagcgc ttagtgaata tgatcaagtt ctcgtggagt cagacaatga gaaccgaatg   2040

gaggaaagca aggctctctt tagaacaatt atcacatacc cctggttcca gaactcctcg   2100

gttattctgt tcttaaacaa gaaagatctt ctagaggaga aaatcatgta ttcccatcta   2160

gtcgactact tcccagaata tgatggaccc cagagagatg cccaggcagc ccgagaattc   2220

attctgaaga tgttcgtgga cctgaaccca gacagtgaca aaattatcta ctcccacttc   2280

acgtgcgcca cagacaccga gaatatccgc tttgtctttg ctgccgtcaa ggacaccatc   2340

ctccagttga acctgaagga tattggtctg ttctaa                             2376


<210>  51
<211>  1167
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SF-human SSTR5

<400>  51
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggagcc cctgttccca gcctccacgc ccagctggaa cgcctcctcc    120

ccgggggctg cctctggagg cggtgacaac aggacgctgg tggggccggc gccctcggca    180

ggggcccggg cggtgctggt gcccgtgctg tacctgctgg tgtgtgcggc cgggctgggc    240

gggaacacgc tggtcatcta cgtggtgctg cgcttcgcca agatgaagac cgtcaccaac    300

atctacattc tcaacctggc agtggccgac gtcctgtaca tgctggggct gcctttcctg    360

gccacgcaga acgccgcgtc cttctggccc ttcggccccg tcctgtgccg cctggtcatg    420

acgctggacg gcgtcaacca gttcaccagt gtcttctgcc tgacagtcat gagcgtggac    480

cgctacctgg cagtggtgca cccgctgagc tcggcccgct ggcgccgccc gcgtgtggcc    540

aagctggcga gcgccgcggc ctgggtcctg tctctgtgca tgtcgctgcc gctcctggtg    600

ttcgcggacg tgcaggaggg cggtacctgc aacgccagct ggccggagcc cgtggggctg    660

tggggcgccg tcttcatcat ctacacggcc gtgctgggct tcttcgcgcc gctgctggtc    720

atctgcctgt gctacctgct catcgtggtg aaggtgaggg cggcgggcgt gcgcgtgggc    780

tgcgtgcggc ggcgctcgga gcggaaggtg acgcgcatgg tgttggtggt ggtgctggtg    840

tttgcgggat gttggctgcc cttcttcacc gtcaacatcg tcaacctggc cgtggcgctg    900

ccccaggagc ccgcctccgc cggcctctac ttcttcgtgg tcatcctctc ctacgccaac    960

agctgtgcca accccgtcct ctacggcttc ctctctgaca acttccgcca gagcttccag   1020

aaggttctgt gcctccgcaa gggctctggt gccaaggacg ctgacgccac ggagccgcgt   1080

ccagacagga tccggcagca gcaggaggcc acgccgcccg cgcaccgcgc cgcagccaac   1140

gggcttatgc agaccagcaa gctgtga                                       1167


<210>  52
<211>  2250
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; SF-human SSTR5Gqi5

<400>  52
atgaagacga tcatcgccct gagctacatc ttctgcctgg tgttcgccga ctacaaggac     60

gatgatgacg ccatggagcc cctgttccca gcctccacgc ccagctggaa cgcctcctcc    120

ccgggggctg cctctggagg cggtgacaac aggacgctgg tggggccggc gccctcggca    180

ggggcccggg cggtgctggt gcccgtgctg tacctgctgg tgtgtgcggc cgggctgggc    240

gggaacacgc tggtcatcta cgtggtgctg cgcttcgcca agatgaagac cgtcaccaac    300

atctacattc tcaacctggc agtggccgac gtcctgtaca tgctggggct gcctttcctg    360

gccacgcaga acgccgcgtc cttctggccc ttcggccccg tcctgtgccg cctggtcatg    420

acgctggacg gcgtcaacca gttcaccagt gtcttctgcc tgacagtcat gagcgtggac    480

cgctacctgg cagtggtgca cccgctgagc tcggcccgct ggcgccgccc gcgtgtggcc    540

aagctggcga gcgccgcggc ctgggtcctg tctctgtgca tgtcgctgcc gctcctggtg    600

ttcgcggacg tgcaggaggg cggtacctgc aacgccagct ggccggagcc cgtggggctg    660

tggggcgccg tcttcatcat ctacacggcc gtgctgggct tcttcgcgcc gctgctggtc    720

atctgcctgt gctacctgct catcgtggtg aaggtgaggg cggcgggcgt gcgcgtgggc    780

tgcgtgcggc ggcgctcgga gcggaaggtg acgcgcatgg tgttggtggt ggtgctggtg    840

tttgcgggat gttggctgcc cttcttcacc gtcaacatcg tcaacctggc cgtggcgctg    900

ccccaggagc ccgcctccgc cggcctctac ttcttcgtgg tcatcctctc ctacgccaac    960

agctgtgcca accccgtcct ctacggcttc ctctctgaca acttccgcca gagcttccag   1020

aaggttctgt gcctccgcaa gggctctggt gccaaggacg ctgacgccac ggagccgcgt   1080

ccagacagga tccggcagca gcaggaggcc acgccgcccg cgcaccgcgc cgcagccaac   1140

gggcttatgc agaccagcaa gctgttcgaa atgactctgg agtccatcat ggcgtgctgc   1200

ctgagcgagg aggccaagga agcccggcgg atcaacgacg agatcgagcg gcagctccgc   1260

agggacaagc gggacgcccg ccgggagctc aagctgctgc tgctcgggac aggagagagt   1320

ggcaagagta cgtttatcaa gcagatgaga atcatccatg ggtcaggata ctctgatgaa   1380

gataaaaggg gcttcaccaa gctggtgtat cagaacatct tcacggccat gcaggccatg   1440

atcagagcca tggacacact caagatccca tacaagtatg agcacaataa ggctcatgca   1500

caattagttc gagaagttga tgtggagaag gtgtctgctt ttgagaatcc atatgtagat   1560

gcaataaaga gtttatggaa tgatcctgga atccaggaat gctatgatag acgacgagaa   1620

tatcaattat ctgactctac caaatactat cttaatgact tggaccgcgt agctgaccct   1680

gcctacctgc ctacgcaaca agatgtgctt agagttcgag tccccaccac agggatcatc   1740

gaatacccct ttgacttaca aagtgtcatt ttcagaatgg tcgatgtagg gggccaaagg   1800

tcagagagaa gaaaatggat acactgcttt gaaaatgtca cctctatcat gtttctagta   1860

gcgcttagtg aatatgatca agttctcgtg gagtcagaca atgagaaccg aatggaggaa   1920

agcaaggctc tctttagaac aattatcaca tacccctggt tccagaactc ctcggttatt   1980

ctgttcttaa acaagaaaga tcttctagag gagaaaatca tgtattccca tctagtcgac   2040

tacttcccag aatatgatgg accccagaga gatgcccagg cagcccgaga attcattctg   2100

aagatgttcg tggacctgaa cccagacagt gacaaaatta tctactccca cttcacgtgc   2160

gccacagaca ccgagaatat ccgctttgtc tttgctgccg tcaaggacac catcctccag   2220

ttgaacctga aggatattgg tctgttctaa                                    2250


<210>  53
<211>  1176
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smyc-human SSTR5

<400>  53
atgaagacga tcatcgccct gagctacatc ttctgcctgg tattcgccga acaaaagctc     60

atttccgaag aggatcttgc catggagccc ctgttcccag cctccacgcc cagctggaac    120

gcctcctccc cgggggctgc ctctggaggc ggtgacaaca ggacgctggt ggggccggcg    180

ccctcggcag gggcccgggc ggtgctggtg cccgtgctgt acctgctggt gtgtgcggcc    240

gggctgggcg ggaacacgct ggtcatctac gtggtgctgc gcttcgccaa gatgaagacc    300

gtcaccaaca tctacattct caacctggca gtggccgacg tcctgtacat gctggggctg    360

cctttcctgg ccacgcagaa cgccgcgtcc ttctggccct tcggccccgt cctgtgccgc    420

ctggtcatga cgctggacgg cgtcaaccag ttcaccagtg tcttctgcct gacagtcatg    480

agcgtggacc gctacctggc agtggtgcac ccgctgagct cggcccgctg gcgccgcccg    540

cgtgtggcca agctggcgag cgccgcggcc tgggtcctgt ctctgtgcat gtcgctgccg    600

ctcctggtgt tcgcggacgt gcaggagggc ggtacctgca acgccagctg gccggagccc    660

gtggggctgt ggggcgccgt cttcatcatc tacacggccg tgctgggctt cttcgcgccg    720

ctgctggtca tctgcctgtg ctacctgctc atcgtggtga aggtgagggc ggcgggcgtg    780

cgcgtgggct gcgtgcggcg gcgctcggag cggaaggtga cgcgcatggt gttggtggtg    840

gtgctggtgt ttgcgggatg ttggctgccc ttcttcaccg tcaacatcgt caacctggcc    900

gtggcgctgc cccaggagcc cgcctccgcc ggcctctact tcttcgtggt catcctctcc    960

tacgccaaca gctgtgccaa ccccgtcctc tacggcttcc tctctgacaa cttccgccag   1020

agcttccaga aggttctgtg cctccgcaag ggctctggtg ccaaggacgc tgacgccacg   1080

gagccgcgtc cagacaggat ccggcagcag caggaggcca cgccgcccgc gcaccgcgcc   1140

gcagccaacg ggcttatgca gaccagcaag ctgtga                             1176


<210>  54
<211>  2625
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; 3HA-M4-linker-Gqi5

<400>  54
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgcttac     60

ccatacgatg ttccagatta cgctgatgcc aacttcacac ctgtcaatgg cagctcgggc    120

aatcagtccg tgcgcctggt cacgtcatca tcccacaatc gctatgagac ggtggaaatg    180

gtcttcattg ccacagtgac aggctccctg agcctggtga ctgtcgtggg caacatcctg    240

gtgatgctgt ccatcaaggt caacaggcag ctgcagacag tcaacaacta cttcctcttc    300

agcctggcgt gtgctgatct catcataggc gccttctcca tgaacctcta caccgtgtac    360

atcatcaagg gctactggcc cctgggcgcc gtggtctgcg acctgtggct ggccctggac    420

tacgtggtga gcaacgcctc cgtcatgaac cttctcatca tcagctttga ccgctacttc    480

tgcgtcacca agcctctcac ctaccctgcc cggcgcacca ccaagatggc aggcctcatg    540

attgctgctg cctgggtact gtccttcgtg ctctgggcgc ctgccatctt gttctggcag    600

tttgtggtgg gtaagcggac ggtgcccgac aaccagtgct tcatccagtt cctgtccaac    660

ccagcagtga cctttggcac agccattgct gccttctacc tgcctgtggt catcatgacg    720

gtgctgtaca tccacatctc cctggccagt cgcagccgag tccacaagca ccggcccgag    780

ggcccgaagg agaagaaagc caagacgctg gccttcctca agagcccact aatgaagcag    840

agcgtcaaga agcccccgcc cggggaggcc gcccgggagg agctgcgcaa tggcaagctg    900

gaggaggccc ccccgccagc gctgccaccg ccaccgcgcc ccgtggctga taaggacact    960

tccaatgagt ccagctcagg cagtgccacc cagaacacca aggaacgccc agccacagag   1020

ctgtccacca cagaggccac cacgcccgcc atgcccgccc ctcccctgca gccgcgggcc   1080

ctcaacccag cctccagatg gtccaagatc cagattgtga cgaagcagac aggcaatgag   1140

tgtgtgacag ccattgagat tgtgcctgcc acgccggctg gcatgcgccc tgcggccaac   1200

gtggcccgca agttcgccag catcgctcgc aaccaggtgc gcaagaagcg gcagatggcg   1260

gcccgggagc gcaaagtgac acgaacgatc tttgccattc tgctagcctt catcctcacc   1320

tggacgccct acaacgtcat ggtcctggtg aacaccttct gccagagctg catccctgac   1380

acggtgtggt ccattggcta ctggctctgc tacgtcaaca gcaccatcaa ccctgcctgc   1440

tatgctctgt gcaacgccac ctttaaaaag accttccggc acctgctgct gtgccagtat   1500

cggaacatcg gcactgccag gttcgaaaga cctgcagacg gtagaatgac tctggagtcc   1560

atcatggcgt gctgcctgag cgaggaggcc aaggaagccc ggcggatcaa cgacgagatc   1620

gagcggcagc tccgcaggga caagcgggac gcccgccggg agctcaagct gctgctgctc   1680

gggacaggag agagtggcaa gagtacgttt atcaagcaga tgagaatcat ccatgggtca   1740

ggatactctg atgaagataa aaggggcttc accaagctgg tgtatcagaa catcttcacg   1800

gccatgcagg ccatgatcag agccatggac acactcaaga tcccatacaa gtatgagcac   1860

aataaggctc atgcacaatt agttcgagaa gttgatgtgg agaaggtgtc tgcttttgag   1920

aatccatatg tagatgcaat aaagagttta tggaatgatc ctggaatcca ggaatgctat   1980

gatagacgac gagaatatca attatctgac tctaccaaat actatcttaa tgacttggac   2040

cgcgtagctg accctgccta cctgcctacg caacaagatg tgcttagagt tcgagtcccc   2100

accacaggga tcatcgaata cccctttgac ttacaaagtg tcattttcag aatggtcgat   2160

gtagggggcc aaaggtcaga gagaagaaaa tggatacact gctttgaaaa tgtcacctct   2220

atcatgtttc tagtagcgct tagtgaatat gatcaagttc tcgtggagtc agacaatgag   2280

aaccgaatgg aggaaagcaa ggctctcttt agaacaatta tcacataccc ctggttccag   2340

aactcctcgg ttattctgtt cttaaacaag aaagatcttc tagaggagaa aatcatgtat   2400

tcccatctag tcgactactt cccagaatat gatggacccc agagagatgc ccaggcagcc   2460

cgagaattca ttctgaagat gttcgtggac ctgaacccag acagtgacaa aattatctac   2520

tcccacttca cgtgcgccac agacaccgag aatatccgct ttgtctttgc tgccgtcaag   2580

gacaccatcc tccagttgaa cctgaaggat attggtctgt tctaa                   2625


<210>  55
<211>  2607
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; 3HA-M4Gqi5a

<400>  55
atgtacccat acgatgttcc agattacgct tacccatacg atgttccaga ttacgcttac     60

ccatacgatg ttccagatta cgctgatgcc aacttcacac ctgtcaatgg cagctcgggc    120

aatcagtccg tgcgcctggt cacgtcatca tcccacaatc gctatgagac ggtggaaatg    180

gtcttcattg ccacagtgac aggctccctg agcctggtga ctgtcgtggg caacatcctg    240

gtgatgctgt ccatcaaggt caacaggcag ctgcagacag tcaacaacta cttcctcttc    300

agcctggcgt gtgctgatct catcataggc gccttctcca tgaacctcta caccgtgtac    360

atcatcaagg gctactggcc cctgggcgcc gtggtctgcg acctgtggct ggccctggac    420

tacgtggtga gcaacgcctc cgtcatgaac cttctcatca tcagctttga ccgctacttc    480

tgcgtcacca agcctctcac ctaccctgcc cggcgcacca ccaagatggc aggcctcatg    540

attgctgctg cctgggtact gtccttcgtg ctctgggcgc ctgccatctt gttctggcag    600

tttgtggtgg gtaagcggac ggtgcccgac aaccagtgct tcatccagtt cctgtccaac    660

ccagcagtga cctttggcac agccattgct gccttctacc tgcctgtggt catcatgacg    720

gtgctgtaca tccacatctc cctggccagt cgcagccgag tccacaagca ccggcccgag    780

ggcccgaagg agaagaaagc caagacgctg gccttcctca agagcccact aatgaagcag    840

agcgtcaaga agcccccgcc cggggaggcc gcccgggagg agctgcgcaa tggcaagctg    900

gaggaggccc ccccgccagc gctgccaccg ccaccgcgcc ccgtggctga taaggacact    960

tccaatgagt ccagctcagg cagtgccacc cagaacacca aggaacgccc agccacagag   1020

ctgtccacca cagaggccac cacgcccgcc atgcccgccc ctcccctgca gccgcgggcc   1080

ctcaacccag cctccagatg gtccaagatc cagattgtga cgaagcagac aggcaatgag   1140

tgtgtgacag ccattgagat tgtgcctgcc acgccggctg gcatgcgccc tgcggccaac   1200

gtggcccgca agttcgccag catcgctcgc aaccaggtgc gcaagaagcg gcagatggcg   1260

gcccgggagc gcaaagtgac acgaacgatc tttgccattc tgctagcctt catcctcacc   1320

tggacgccct acaacgtcat ggtcctggtg aacaccttct gccagagctg catccctgac   1380

acggtgtggt ccattggcta ctggctctgc tacgtcaaca gcaccatcaa ccctgcctgc   1440

tatgctctgt gcaacgccac ctttaaaaag accttccggc acctgctgct gtgccagtat   1500

cggaacatcg gcactgccag gttcgaaatg actctggagt ccatcatggc gtgctgcctg   1560

agcgaggagg ccaaggaagc ccggcggatc aacgacgaga tcgagcggca gctccgcagg   1620

gacaagcggg acgcccgccg ggagctcaag ctgctgctgc tcgggacagg agagagtggc   1680

aagagtacgt ttatcaagca gatgagaatc atccatgggt caggatactc tgatgaagat   1740

aaaaggggct tcaccaagct ggtgtatcag aacatcttca cggccatgca ggccatgatc   1800

agagccatgg acacactcaa gatcccatac aagtatgagc acaataaggc tcatgcacaa   1860

ttagttcgag aagttgatgt ggagaaggtg tctgcttttg agaatccata tgtagatgca   1920

ataaagagtt tatggaatga tcctggaatc caggaatgct atgatagacg acgagaatat   1980

caattatctg actctaccaa atactatctt aatgacttgg accgcgtagc tgaccctgcc   2040

tacctgccta cgcaacaaga tgtgcttaga gttcgagtcc ccaccacagg gatcatcgaa   2100

tacccctttg acttacaaag tgtcattttc agaatggtcg atgtaggggg ccaaaggtca   2160

gagagaagaa aatggataca ctgctttgaa aatgtcacct ctatcatgtt tctagtagcg   2220

cttagtgaat atgatcaagt tctcgtggag tcagacaatg agaaccgaat ggaggaaagc   2280

aaggctctct ttagaacaat tatcacatac ccctggttcc agaactcctc ggttattctg   2340

ttcttaaaca agaaagatct tctagaggag aaaatcatgt attcccatct agtcgactac   2400

ttcccagaat atgatggacc ccagagagat gcccaggcag cccgagaatt cattctgaag   2460

atgttcgtgg acctgaaccc agacagtgac aaaattatct actcccactt cacgtgcgcc   2520

acagacaccg agaatatccg ctttgtcttt gctgccgtca aggacaccat cctccagttg   2580

aacctgaagg atattggtct gttctaa                                       2607


<210>  56
<211>  1059
<212>  DNA
<213>  Homo sapiens

<400>  56
atggattatc aagtgtcaag tccaatctat gacatcaatt attatacatc ggagccctgc     60

caaaaaatca atgtgaagca aatcgcagcc cgcctcctgc ctccgctcta ctcactggtg    120

ttcatctttg gttttgtggg caacatgctg gtcatcctca tcctgataaa ctgcaaaagg    180

ctgaagagca tgactgacat ctacctgctc aacctggcca tctctgacct gtttttcctt    240

cttactgtcc ccttctgggc tcactatgct gccgcccagt gggactttgg aaatacaatg    300

tgtcaactct tgacagggct ctattttata ggcttcttct ctggaatctt cttcatcatc    360

ctcctgacaa tcgataggta cctggctgtc gtccatgctg tgtttgcttt aaaagccagg    420

acggtcacct ttggggtggt gacaagtgtg atcacttggg tggtggctgt gtttgcgtct    480

ctcccaggaa tcatctttac cagatctcaa aaagaaggtc ttcattacac ctgcagctct    540

cattttccat acagtcagta tcaattctgg aagaatttcc agacattaaa gatagtcatc    600

ttggggctgg tcctgccgct gcttgtcatg gtcatctgct actcgggaat cctaaaaact    660

ctgcttcggt gtcgaaatga gaagaagagg cacagggctg tgaggcttat cttcaccatc    720

atgattgttt attttctctt ctgggctccc tacaacattg tccttctcct gaacaccttc    780

caggaattct ttggcctgaa taattgcagt agctctaaca ggttggacca agctatgcag    840

gtgacagaga ctcttgggat gacgcactgc tgcatcaacc ccatcatcta tgcctttgtc    900

ggggagaagt tcagaaacta cctcttagtc ttcttccaaa agcacattgc caaacgcttc    960

tgcaaatgct gttctatttt ccagcaagag gctcccgagc gagcaagctc agtttacacc   1020

cgatccactg gggagcagga aatatctgtg ggcttgtga                          1059


<210>  57
<211>  2142
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; CCR5 Gqi5

<400>  57
atggattatc aagtgtcaag tccaatctat gacatcaatt attatacatc ggagccctgc     60

caaaaaatca atgtgaagca aatcgcagcc cgcctcctgc ctccgctcta ctcactggtg    120

ttcatctttg gttttgtggg caacatgctg gtcatcctca tcctgataaa ctgcaaaagg    180

ctgaagagca tgactgacat ctacctgctc aacctggcca tctctgacct gtttttcctt    240

cttactgtcc ccttctgggc tcactatgct gccgcccagt gggactttgg aaatacaatg    300

tgtcaactct tgacagggct ctattttata ggcttcttct ctggaatctt cttcatcatc    360

ctcctgacaa tcgataggta cctggctgtc gtccatgctg tgtttgcttt aaaagccagg    420

acggtcacct ttggggtggt gacaagtgtg atcacttggg tggtggctgt gtttgcgtct    480

ctcccaggaa tcatctttac cagatctcaa aaagaaggtc ttcattacac ctgcagctct    540

cattttccat acagtcagta tcaattctgg aagaatttcc agacattaaa gatagtcatc    600

ttggggctgg tcctgccgct gcttgtcatg gtcatctgct actcgggaat cctaaaaact    660

ctgcttcggt gtcgaaatga gaagaagagg cacagggctg tgaggcttat cttcaccatc    720

atgattgttt attttctctt ctgggctccc tacaacattg tccttctcct gaacaccttc    780

caggaattct ttggcctgaa taattgcagt agctctaaca ggttggacca agctatgcag    840

gtgacagaga ctcttgggat gacgcactgc tgcatcaacc ccatcatcta tgcctttgtc    900

ggggagaagt tcagaaacta cctcttagtc ttcttccaaa agcacattgc caaacgcttc    960

tgcaaatgct gttctatttt ccagcaagag gctcccgagc gagcaagctc agtttacacc   1020

cgatccactg gggagcagga aatatctgtg ggcttgttcg aaatgactct ggagtccatc   1080

atggcgtgct gcctgagcga ggaggccaag gaagcccggc ggatcaacga cgagatcgag   1140

cggcagctcc gcagggacaa gcgggacgcc cgccgggagc tcaagctgct gctgctcggg   1200

acaggagaga gtggcaagag tacgtttatc aagcagatga gaatcatcca tgggtcagga   1260

tactctgatg aagataaaag gggcttcacc aagctggtgt atcagaacat cttcacggcc   1320

atgcaggcca tgatcagagc catggacaca ctcaagatcc catacaagta tgagcacaat   1380

aaggctcatg cacaattagt tcgagaagtt gatgtggaga aggtgtctgc ttttgagaat   1440

ccatatgtag atgcaataaa gagtttatgg aatgatcctg gaatccagga atgctatgat   1500

agacgacgag aatatcaatt atctgactct accaaatact atcttaatga cttggaccgc   1560

gtagctgacc ctgcctacct gcctacgcaa caagatgtgc ttagagttcg agtccccacc   1620

acagggatca tcgaataccc ctttgactta caaagtgtca ttttcagaat ggtcgatgta   1680

gggggccaaa ggtcagagag aagaaaatgg atacactgct ttgaaaatgt cacctctatc   1740

atgtttctag tagcgcttag tgaatatgat caagttctcg tggagtcaga caatgagaac   1800

cgaatggagg aaagcaaggc tctctttaga acaattatca catacccctg gttccagaac   1860

tcctcggtta ttctgttctt aaacaagaaa gatcttctag aggagaaaat catgtattcc   1920

catctagtcg actacttccc agaatatgat ggaccccaga gagatgccca ggcagcccga   1980

gaattcattc tgaagatgtt cgtggacctg aacccagaca gtgacaaaat tatctactcc   2040

cacttcacgt gcgccacaga caccgagaat atccgctttg tctttgctgc cgtcaaggac   2100

accatcctcc agttgaacct gaaggatatt ggtctgttct aa                      2142


<210>  58
<211>  1200
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; smycDOR

<400>  58
atgaagacga tcatcgccct gagctacatc ttctgcctgg tattcgccga acaaaagctc     60

atttccgaag aggatcttgc catggagctg gtgccctctg cccgtgcgga gctgcagtcc    120

tcgcccctcg tcaacctctc ggacgccttt cccagcgcct tccccagcgc gggcgccaat    180

gcgtcggggt cgccgggagc ccgtagtgcc tcgtccctcg ccctagccat cgccatcacc    240

gcgctctact cggctgtgtg cgcagtgggg cttctgggca acgtgctcgt catgtttggc    300

atcgtccggt acaccaaatt gaagaccgcc accaacatct acatcttcaa tctggctttg    360

gctgatgcgc tggccaccag cacgctgccc ttccagagcg ccaagtactt gatggaaacg    420

tggccgtttg gcgagctgct gtgcaaggct gtgctctcca ttgactacta caacatgttc    480

actagcatct tcaccctcac catgatgagc gtggaccgct acattgctgt ctgccatcct    540

gtcaaagccc tggacttccg gacaccagcc aaggccaagc tgatcaatat atgcatctgg    600

gtcttggctt caggtgtcgg ggtccccatc atggtcatgg cagtgaccca accccgggat    660

ggtgcagtgg tatgcatgct ccagttcccc agtcccagct ggtactggga cactgtgacc    720

aagatctgcg tgttcctctt tgccttcgtg gtgccgatcc tcatcatcac ggtgtgctat    780

ggcctcatgc tactgcgcct gcgcagcgtg cgtctgctgt ccggttccaa ggagaaggac    840

cgcagcctgc ggcgcatcac gcgcatggtg ctggtggtgg tgggcgcctt cgtggtgtgc    900

tgggcgccca tccacatctt cgtcatcgtc tggacgctgg tggacatcaa tcggcgcgac    960

ccacttgtgg tggccgcact gcacctgtgc attgcgctgg gctacgccaa cagcagcctc   1020

aacccggttc tctacgcctt cctggacgag aacttcaagc gctgcttccg ccagctctgt   1080

cgcacgccct gcggccgcca agaacccggc agtctccgtc gtccccgcca ggccaccacg   1140

cgtgagcgtg tcactgcctg caccccctcc gacggcccgg gcggtggcgc tgccgcctga   1200


<210>  59
<211>  3378
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; TSHr Gqi5

<400>  59
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc     60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc    120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt    180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga    240

atctacgtat ctatagatct gactctgcag cagctggaat cacactcctt ctacaatttg    300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat    360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg    420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac    480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg    540

acactgaagc tgtacaacaa tggctttact tcagtccaag gatatgcttt caatgggaca    600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca    660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc    720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt    780

aagaaacttc cactttcctt gagtttcctt cacctcacac gggctgacct ttcttaccca    840

agccactgct gtgcttttaa gaatcagaag aaaatcagag gaatccttga gtccttgatg    900

tgtaatgaga gcagtatgca gagcttgcgc cagagaaaat ctgtgaatgc cttgaatagc    960

cccctccacc aggaatatga agagaatctg ggtgacagca ttgttgggta caaggaaaag   1020

tccaagttcc aggatactca taacaacgct cattattacg tcttctttga agaacaagag   1080

gatgagatca ttggttttgg ccaggagctc aaaaaccccc aggaagagac tctacaagct   1140

tttgacagcc attatgacta caccatatgt ggggacagtg aagacatggt gtgtaccccc   1200

aagtccgatg agttcaaccc gtgtgaagac ataatgggct acaagttcct gagaattgtg   1260

gtgtggttcg ttagtctgct ggctctcctg ggcaatgtct ttgtcctgct tattctcctc   1320

accagccact acaaactgaa cgtcccccgc tttctcatgt gcaacctggc ctttgcggat   1380

ttctgcatgg ggatgtacct gctcctcatc gcctctgtag acctctacac tcactctgag   1440

tactacaacc atgccatcga ctggcagaca ggccctgggt gcaacacggc tggtttcttc   1500

actgtctttg caagcgagtt atcggtgtat acgctgacgg tcatcaccct ggagcgctgg   1560

tatgccatca ccttcgccat gcgcctggac cggaagatcc gcctcaggca cgcatgtgcc   1620

atcatggttg ggggctgggt ttgctgcttc cttctcgccc tgcttccttt ggtgggaata   1680

agtagctatg ccaaagtcag tatctgcctg cccatggaca ccgagacccc tcttgctctg   1740

gcatatattg tttttgttct gacgctcaac atagttgcct tcgtcatcgt ctgctgctgt   1800

tatgtgaaga tctacatcac agtccgaaat ccgcagtaca acccagggga caaagatacc   1860

aaaattgcca agaggatggc tgtgttgatc ttcaccgact tcatatgcat ggccccaatc   1920

tcattctatg ctctgtcagc aattctgaac aagcctctca tcactgttag caactccaaa   1980

atcttgctgg tactcttcta tccacttaac tcctgtgcca atccattcct ctatgctatt   2040

ttcaccaagg ccttccagag ggatgtgttc atcctactca gcaagtttgg catctgtaaa   2100

cgccaggctc aggcataccg ggggcagagg gttcctccaa agaacagcac tgatattcag   2160

gttcaaaagg ttacccacga catgaggcag ggtctccaca acatggaaga tgtctatgaa   2220

ctgattgaaa actcccatct aaccccaaag aagcaaggcc aaatctcaga agagtatatg   2280

caaacggttt tgttcgaaat gactctggag tccatcatgg cgtgctgcct gagcgaggag   2340

gccaaggaag cccggcggat caacgacgag atcgagcggc agctccgcag ggacaagcgg   2400

gacgcccgcc gggagctcaa gctgctgctg ctcgggacag gagagagtgg caagagtacg   2460

tttatcaagc agatgagaat catccatggg tcaggatact ctgatgaaga taaaaggggc   2520

ttcaccaagc tggtgtatca gaacatcttc acggccatgc aggccatgat cagagccatg   2580

gacacactca agatcccata caagtatgag cacaataagg ctcatgcaca attagttcga   2640

gaagttgatg tggagaaggt gtctgctttt gagaatccat atgtagatgc aataaagagt   2700

ttatggaatg atcctggaat ccaggaatgc tatgatagac gacgagaata tcaattatct   2760

gactctacca aatactatct taatgacttg gaccgcgtag ctgaccctgc ctacctgcct   2820

acgcaacaag atgtgcttag agttcgagtc cccaccacag ggatcatcga ataccccttt   2880

gacttacaaa gtgtcatttt cagaatggtc gatgtagggg gccaaaggtc agagagaaga   2940

aaatggatac actgctttga aaatgtcacc tctatcatgt ttctagtagc gcttagtgaa   3000

tatgatcaag ttctcgtgga gtcagacaat gagaaccgaa tggaggaaag caaggctctc   3060

tttagaacaa ttatcacata cccctggttc cagaactcct cggttattct gttcttaaac   3120

aagaaagatc ttctagagga gaaaatcatg tattcccatc tagtcgacta cttcccagaa   3180

tatgatggac cccagagaga tgcccaggca gcccgagaat tcattctgaa gatgttcgtg   3240

gacctgaacc cagacagtga caaaattatc tactcccact tcacgtgcgc cacagacacc   3300

gagaatatcc gctttgtctt tgctgccgtc aaggacacca tcctccagtt gaacctgaag   3360

gatattggtc tgttctaa                                                 3378


<210>  60
<211>  1245
<212>  DNA
<213>  Homo sapiens

<400>  60
atggatccac tgaatctgtc ctggtatgat gatgatctgg agaggcagaa ctggagccgg     60

cccttcaacg ggtcagacgg gaaggcggac agaccccact acaactacta tgccacactg    120

ctcaccctgc tcatcgctgt catcgtcttc ggcaacgtgc tggtgtgcat ggctgtgtcc    180

cgcgagaagg cgctgcagac caccaccaac tacctgatcg tcagcctcgc agtggccgac    240

ctcctcgtcg ccacactggt catgccctgg gttgtctacc tggaggtggt aggtgagtgg    300

aaattcagca ggattcactg tgacatcttc gtcactctgg acgtcatgat gtgcacggcg    360

agcatcctga acttgtgtgc catcagcatc gacaggtaca cagctgtggc catgcccatg    420

ctgtacaata cgcgctacag ctccaagcgc cgggtcaccg tcatgatctc catcgtctgg    480

gtcctgtcct tcaccatctc ctgcccactc ctcttcggac tcaataacgc agaccagaac    540

gagtgcatca ttgccaaccc ggccttcgtg gtctactcct ccatcgtctc cttctacgtg    600

cccttcattg tcaccctgct ggtctacatc aagatctaca ttgtcctccg cagacgccgc    660

aagcgagtca acaccaaacg cagcagccga gctttcaggg cccacctgag ggctccacta    720

aaggaggctg cccggcgagc ccaggagctg gagatggaga tgctctccag caccagccca    780

cccgagagga cccggtacag ccccatccca cccagccacc accagctgac tctccccgac    840

ccgtcccacc atggtctcca cagcactccc gacagccccg ccaaaccaga gaagaatggg    900

catgccaaag accaccccaa gattgccaag atctttgaga tccagaccat gcccaatggc    960

aaaacgcgta cctccctcaa gaccatgagc cgtaggaagc tctcccagca gaaggagaag   1020

aaagccactc agatgctcgc cattgttctc ggcgtgttca tcatctgctg gctgcccttc   1080

ttcatcacac acatcctgaa catacactgt gactgcaaca tcccgcctgt cctgtacagc   1140

gccttcacgt ggctgggcta tgtcaacagc gccgtgaacc ccatcatcta caccaccttc   1200

aacattgagt tccgcaaggc cttcctgaag atcctccact gctga                   1245


<210>  61
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Glu Ala Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser 
                245                 250                 255     


Ser Thr Ser Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser 
            260                 265                 270         


His His Gln Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser 
        275                 280                 285             


Thr Pro Asp Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp 
    290                 295                 300                 


His Pro Lys Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly 
305                 310                 315                 320 


Lys Thr Arg Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln 
                325                 330                 335     


Gln Lys Glu Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val 
            340                 345                 350         


Phe Ile Ile Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile 
        355                 360                 365             


His Cys Asp Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp 
    370                 375                 380                 


Leu Gly Tyr Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe 
385                 390                 395                 400 


Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
                405                 410                 


<210>  62
<211>  1317
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct; hD2 with signal sequence and FLAG tag

<400>  62
atgaagacga tcatcgccct gagctacatc ttctgcctgg tattcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgctga      1317


<210>  63
<211>  438
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct; hD2 with signal and FLAG

<400>  63

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Pro Leu Asn Leu Ser Trp 
            20                  25                  30          


Tyr Asp Asp Asp Leu Glu Arg Gln Asn Trp Ser Arg Pro Phe Asn Gly 
        35                  40                  45              


Ser Asp Gly Lys Ala Asp Arg Pro His Tyr Asn Tyr Tyr Ala Thr Leu 
    50                  55                  60                  


Leu Thr Leu Leu Ile Ala Val Ile Val Phe Gly Asn Val Leu Val Cys 
65                  70                  75                  80  


Met Ala Val Ser Arg Glu Lys Ala Leu Gln Thr Thr Thr Asn Tyr Leu 
                85                  90                  95      


Ile Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr Leu Val Met 
            100                 105                 110         


Pro Trp Val Val Tyr Leu Glu Val Val Gly Glu Trp Lys Phe Ser Arg 
        115                 120                 125             


Ile His Cys Asp Ile Phe Val Thr Leu Asp Val Met Met Cys Thr Ala 
    130                 135                 140                 


Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg Tyr Thr Ala Val 
145                 150                 155                 160 


Ala Met Pro Met Leu Tyr Asn Thr Arg Tyr Ser Ser Lys Arg Arg Val 
                165                 170                 175     


Thr Val Met Ile Ser Ile Val Trp Val Leu Ser Phe Thr Ile Ser Cys 
            180                 185                 190         


Pro Leu Leu Phe Gly Leu Asn Asn Ala Asp Gln Asn Glu Cys Ile Ile 
        195                 200                 205             


Ala Asn Pro Ala Phe Val Val Tyr Ser Ser Ile Val Ser Phe Tyr Val 
    210                 215                 220                 


Pro Phe Ile Val Thr Leu Leu Val Tyr Ile Lys Ile Tyr Ile Val Leu 
225                 230                 235                 240 


Arg Arg Arg Arg Lys Arg Val Asn Thr Lys Arg Ser Ser Arg Ala Phe 
                245                 250                 255     


Arg Ala His Leu Arg Ala Pro Leu Lys Glu Ala Ala Arg Arg Ala Gln 
            260                 265                 270         


Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser Pro Pro Glu Arg Thr 
        275                 280                 285             


Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln Leu Thr Leu Pro Asp 
    290                 295                 300                 


Pro Ser His His Gly Leu His Ser Thr Pro Asp Ser Pro Ala Lys Pro 
305                 310                 315                 320 


Glu Lys Asn Gly His Ala Lys Asp His Pro Lys Ile Ala Lys Ile Phe 
                325                 330                 335     


Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg Thr Ser Leu Lys Thr 
            340                 345                 350         


Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu Lys Lys Ala Thr Gln 
        355                 360                 365             


Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile Cys Trp Leu Pro Phe 
    370                 375                 380                 


Phe Ile Thr His Ile Leu Asn Ile His Cys Asp Cys Asn Ile Pro Pro 
385                 390                 395                 400 


Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr Val Asn Ser Ala Val 
                405                 410                 415     


Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu Phe Arg Lys Ala Phe 
            420                 425                 430         


Leu Lys Ile Leu His Cys 
        435             


<210>  64
<211>  799
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct; SFD2sWTGqi5

<400>  64

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Pro Leu Asn Leu Ser Trp 
            20                  25                  30          


Tyr Asp Asp Asp Leu Glu Arg Gln Asn Trp Ser Arg Pro Phe Asn Gly 
        35                  40                  45              


Ser Asp Gly Lys Ala Asp Arg Pro His Tyr Asn Tyr Tyr Ala Thr Leu 
    50                  55                  60                  


Leu Thr Leu Leu Ile Ala Val Ile Val Phe Gly Asn Val Leu Val Cys 
65                  70                  75                  80  


Met Ala Val Ser Arg Glu Lys Ala Leu Gln Thr Thr Thr Asn Tyr Leu 
                85                  90                  95      


Ile Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr Leu Val Met 
            100                 105                 110         


Pro Trp Val Val Tyr Leu Glu Val Val Gly Glu Trp Lys Phe Ser Arg 
        115                 120                 125             


Ile His Cys Asp Ile Phe Val Thr Leu Asp Val Met Met Cys Thr Ala 
    130                 135                 140                 


Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg Tyr Thr Ala Val 
145                 150                 155                 160 


Ala Met Pro Met Leu Tyr Asn Thr Arg Tyr Ser Ser Lys Arg Arg Val 
                165                 170                 175     


Thr Val Met Ile Ser Ile Val Trp Val Leu Ser Phe Thr Ile Ser Cys 
            180                 185                 190         


Pro Leu Leu Phe Gly Leu Asn Asn Ala Asp Gln Asn Glu Cys Ile Ile 
        195                 200                 205             


Ala Asn Pro Ala Phe Val Val Tyr Ser Ser Ile Val Ser Phe Tyr Val 
    210                 215                 220                 


Pro Phe Ile Val Thr Leu Leu Val Tyr Ile Lys Ile Tyr Ile Val Leu 
225                 230                 235                 240 


Arg Arg Arg Arg Lys Arg Val Asn Thr Lys Arg Ser Ser Arg Ala Phe 
                245                 250                 255     


Arg Ala His Leu Arg Ala Pro Leu Lys Glu Ala Ala Arg Arg Ala Gln 
            260                 265                 270         


Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser Pro Pro Glu Arg Thr 
        275                 280                 285             


Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln Leu Thr Leu Pro Asp 
    290                 295                 300                 


Pro Ser His His Gly Leu His Ser Thr Pro Asp Ser Pro Ala Lys Pro 
305                 310                 315                 320 


Glu Lys Asn Gly His Ala Lys Asp His Pro Lys Ile Ala Lys Ile Phe 
                325                 330                 335     


Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg Thr Ser Leu Lys Thr 
            340                 345                 350         


Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu Lys Lys Ala Thr Gln 
        355                 360                 365             


Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile Cys Trp Leu Pro Phe 
    370                 375                 380                 


Phe Ile Thr His Ile Leu Asn Ile His Cys Asp Cys Asn Ile Pro Pro 
385                 390                 395                 400 


Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr Val Asn Ser Ala Val 
                405                 410                 415     


Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu Phe Arg Lys Ala Phe 
            420                 425                 430         


Leu Lys Ile Leu His Cys Phe Glu Met Thr Leu Glu Ser Ile Met Ala 
        435                 440                 445             


Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala Arg Arg Ile Asn Asp Glu 
    450                 455                 460                 


Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg Asp Ala Arg Arg Glu Leu 
465                 470                 475                 480 


Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys Ser Thr Phe Ile 
                485                 490                 495     


Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser Asp Glu Asp Lys 
            500                 505                 510         


Arg Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe Thr Ala Met Gln 
        515                 520                 525             


Ala Met Ile Arg Ala Met Asp Thr Leu Lys Ile Pro Tyr Lys Tyr Glu 
    530                 535                 540                 


His Asn Lys Ala His Ala Gln Leu Val Arg Glu Val Asp Val Glu Lys 
545                 550                 555                 560 


Val Ser Ala Phe Glu Asn Pro Tyr Val Asp Ala Ile Lys Ser Leu Trp 
                565                 570                 575     


Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg Arg Glu Tyr Gln 
            580                 585                 590         


Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu Asp Arg Val Ala 
        595                 600                 605             


Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu Arg Val Arg Val 
    610                 615                 620                 


Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu Gln Ser Val Ile 
625                 630                 635                 640 


Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg Arg Lys Trp 
                645                 650                 655     


Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe Leu Val Ala Leu 
            660                 665                 670         


Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn Glu Asn Arg Met 
        675                 680                 685             


Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr Tyr Pro Trp Phe 
    690                 695                 700                 


Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys Asp Leu Leu Glu 
705                 710                 715                 720 


Glu Lys Ile Met Tyr Ser His Leu Val Asp Tyr Phe Pro Glu Tyr Asp 
                725                 730                 735     


Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe Ile Leu Lys Met 
            740                 745                 750         


Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile Tyr Ser His Phe 
        755                 760                 765             


Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val Phe Ala Ala Val 
    770                 775                 780                 


Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Asp Ile Gly Leu Phe 
785                 790                 795                 


<210>  65
<211>  439
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; sMycD2sWT

<400>  65

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Pro Leu Asn Leu Ser 
            20                  25                  30          


Trp Tyr Asp Asp Asp Leu Glu Arg Gln Asn Trp Ser Arg Pro Phe Asn 
        35                  40                  45              


Gly Ser Asp Gly Lys Ala Asp Arg Pro His Tyr Asn Tyr Tyr Ala Thr 
    50                  55                  60                  


Leu Leu Thr Leu Leu Ile Ala Val Ile Val Phe Gly Asn Val Leu Val 
65                  70                  75                  80  


Cys Met Ala Val Ser Arg Glu Lys Ala Leu Gln Thr Thr Thr Asn Tyr 
                85                  90                  95      


Leu Ile Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr Leu Val 
            100                 105                 110         


Met Pro Trp Val Val Tyr Leu Glu Val Val Gly Glu Trp Lys Phe Ser 
        115                 120                 125             


Arg Ile His Cys Asp Ile Phe Val Thr Leu Asp Val Met Met Cys Thr 
    130                 135                 140                 


Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg Tyr Thr Ala 
145                 150                 155                 160 


Val Ala Met Pro Met Leu Tyr Asn Thr Arg Tyr Ser Ser Lys Arg Arg 
                165                 170                 175     


Val Thr Val Met Ile Ser Ile Val Trp Val Leu Ser Phe Thr Ile Ser 
            180                 185                 190         


Cys Pro Leu Leu Phe Gly Leu Asn Asn Ala Asp Gln Asn Glu Cys Ile 
        195                 200                 205             


Ile Ala Asn Pro Ala Phe Val Val Tyr Ser Ser Ile Val Ser Phe Tyr 
    210                 215                 220                 


Val Pro Phe Ile Val Thr Leu Leu Val Tyr Ile Lys Ile Tyr Ile Val 
225                 230                 235                 240 


Leu Arg Arg Arg Arg Lys Arg Val Asn Thr Lys Arg Ser Ser Arg Ala 
                245                 250                 255     


Phe Arg Ala His Leu Arg Ala Pro Leu Lys Glu Ala Ala Arg Arg Ala 
            260                 265                 270         


Gln Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser Pro Pro Glu Arg 
        275                 280                 285             


Thr Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln Leu Thr Leu Pro 
    290                 295                 300                 


Asp Pro Ser His His Gly Leu His Ser Thr Pro Asp Ser Pro Ala Lys 
305                 310                 315                 320 


Pro Glu Lys Asn Gly His Ala Lys Asp His Pro Lys Ile Ala Lys Ile 
                325                 330                 335     


Phe Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg Thr Ser Leu Lys 
            340                 345                 350         


Thr Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu Lys Lys Ala Thr 
        355                 360                 365             


Gln Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile Cys Trp Leu Pro 
    370                 375                 380                 


Phe Phe Ile Thr His Ile Leu Asn Ile His Cys Asp Cys Asn Ile Pro 
385                 390                 395                 400 


Pro Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr Val Asn Ser Ala 
                405                 410                 415     


Val Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu Phe Arg Lys Ala 
            420                 425                 430         


Phe Leu Lys Ile Leu His Cys 
        435                 


<210>  66
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Gly Asn Cys Thr His Pro Glu Asp Met Lys Leu Cys Thr Val Ile 
                245                 250                 255     


Met Lys Ser Asn Gly Ser Phe Pro Val Asn Arg Arg Arg Val Glu Ala 
            260                 265                 270         


Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser 
        275                 280                 285             


Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln 
    290                 295                 300                 


Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser Thr Pro Asp 
305                 310                 315                 320 


Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp His Pro Lys 
                325                 330                 335     


Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg 
            340                 345                 350         


Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu 
        355                 360                 365             


Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile 
    370                 375                 380                 


Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile His Cys Asp 
385                 390                 395                 400 


Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr 
                405                 410                 415     


Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu 
            420                 425                 430         


Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
        435                 440             


<210>  67
<211>  1080
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct; Gqi5

<400>  67
atgactctgg agtccatcat ggcgtgctgc ctgagcgagg aggccaagga agcccggcgg     60

atcaacgacg agatcgagcg gcagctccgc agggacaagc gggacgcccg ccgggagctc    120

aagctgctgc tgctcgggac aggagagagt ggcaagagta cgtttatcaa gcagatgaga    180

atcatccatg ggtcaggata ctctgatgaa gataaaaggg gcttcaccaa gctggtgtat    240

cagaacatct tcacggccat gcaggccatg atcagagcca tggacacact caagatccca    300

tacaagtatg agcacaataa ggctcatgca caattagttc gagaagttga tgtggagaag    360

gtgtctgctt ttgagaatcc atatgtagat gcaataaaga gtttatggaa tgatcctgga    420

atccaggaat gctatgatag acgacgagaa tatcaattat ctgactctac caaatactat    480

cttaatgact tggaccgcgt agctgaccct gcctacctgc ctacgcaaca agatgtgctt    540

agagttcgag tccccaccac agggatcatc gaatacccct ttgacttaca aagtgtcatt    600

ttcagaatgg tcgatgtagg gggccaaagg tcagagagaa gaaaatggat acactgcttt    660

gaaaatgtca cctctatcat gtttctagta gcgcttagtg aatatgatca agttctcgtg    720

gagtcagaca atgagaaccg aatggaggaa agcaaggctc tctttagaac aattatcaca    780

tacccctggt tccagaactc ctcggttatt ctgttcttaa acaagaaaga tcttctagag    840

gagaaaatca tgtattccca tctagtcgac tacttcccag aatatgatgg accccagaga    900

gatgcccagg cagcccgaga attcattctg aagatgttcg tggacctgaa cccagacagt    960

gacaaaatta tctactccca cttcacgtgc gccacagaca ccgagaatat ccgctttgtc   1020

tttgctgccg tcaaggacac catcctccag ttgaacctga aggatattgg tctgttctaa   1080


<210>  68
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct, Gqi5

<400>  68

Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys 
1               5                   10                  15      


Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp 
            20                  25                  30          


Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 
        35                  40                  45              


Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 
    50                  55                  60                  


Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 
65                  70                  75                  80  


Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr 
                85                  90                  95      


Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu 
            100                 105                 110         


Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr 
        115                 120                 125             


Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr 
145                 150                 155                 160 


Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln 
                165                 170                 175     


Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 
            180                 185                 190         


Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly 
        195                 200                 205             


Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 
    210                 215                 220                 


Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 
225                 230                 235                 240 


Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 
                245                 250                 255     


Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 
            260                 265                 270         


Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu 
        275                 280                 285             


Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala 
    290                 295                 300                 


Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 
305                 310                 315                 320 


Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 
                325                 330                 335     


Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 
            340                 345                 350         


Leu Lys Asp Ile Gly Leu Phe 
        355                 


<210>  69
<211>  2418
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct; flag-tagged D2s-linker-Gqi5

<400>  69
atgaagacga tcatcgccct gagctacatc ttctgcctgg tattcgccga ctacaaggac     60

gatgatgacg ccatggatcc actgaatctg tcctggtatg atgatgatct ggagaggcag    120

aactggagcc ggcccttcaa cgggtcagac gggaaggcgg acagacccca ctacaactac    180

tatgccacac tgctcaccct gctcatcgct gtcatcgtct tcggcaacgt gctggtgtgc    240

atggctgtgt cccgcgagaa ggcgctgcag accaccacca actacctgat cgtcagcctc    300

gcagtggccg acctcctcgt cgccacactg gtcatgccct gggttgtcta cctggaggtg    360

gtaggtgagt ggaaattcag caggattcac tgtgacatct tcgtcactct ggacgtcatg    420

atgtgcacgg cgagcatcct gaacttgtgt gccatcagca tcgacaggta cacagctgtg    480

gccatgccca tgctgtacaa tacgcgctac agctccaagc gccgggtcac cgtcatgatc    540

tccatcgtct gggtcctgtc cttcaccatc tcctgcccac tcctcttcgg actcaataac    600

gcagaccaga acgagtgcat cattgccaac ccggccttcg tggtctactc ctccatcgtc    660

tccttctacg tgcccttcat tgtcaccctg ctggtctaca tcaagatcta cattgtcctc    720

cgcagacgcc gcaagcgagt caacaccaaa cgcagcagcc gagctttcag ggcccacctg    780

agggctccac taaaggaggc tgcccggcga gcccaggagc tggagatgga gatgctctcc    840

agcaccagcc cacccgagag gacccggtac agccccatcc cacccagcca ccaccagctg    900

actctccccg acccgtccca ccatggtctc cacagcactc ccgacagccc cgccaaacca    960

gagaagaatg ggcatgccaa agaccacccc aagattgcca agatctttga gatccagacc   1020

atgcccaatg gcaaaacgcg tacctccctc aagaccatga gccgtaggaa gctctcccag   1080

cagaaggaga agaaagccac tcagatgctc gccattgttc tcggcgtgtt catcatctgc   1140

tggctgccct tcttcatcac acacatcctg aacatacact gtgactgcaa catcccgcct   1200

gtcctgtaca gcgccttcac gtggctgggc tatgtcaaca gcgccgtgaa ccccatcatc   1260

tacaccacct tcaacattga gttccgcaag gccttcctga agatcctcca ctgtttcgaa   1320

agacctgcag acggtagaat gactctggag tccatcatgg cgtgctgcct gagcgaggag   1380

gccaaggaag cccggcggat caacgacgag atcgagcggc agctccgcag ggacaagcgg   1440

gacgcccgcc gggagctcaa gctgctgctg ctcgggacag gagagagtgg caagagtacg   1500

tttatcaagc agatgagaat catccatggg tcaggatact ctgatgaaga taaaaggggc   1560

ttcaccaagc tggtgtatca gaacatcttc acggccatgc aggccatgat cagagccatg   1620

gacacactca agatcccata caagtatgag cacaataagg ctcatgcaca attagttcga   1680

gaagttgatg tggagaaggt gtctgctttt gagaatccat atgtagatgc aataaagagt   1740

ttatggaatg atcctggaat ccaggaatgc tatgatagac gacgagaata tcaattatct   1800

gactctacca aatactatct taatgacttg gaccgcgtag ctgaccctgc ctacctgcct   1860

acgcaacaag atgtgcttag agttcgagtc cccaccacag ggatcatcga ataccccttt   1920

gacttacaaa gtgtcatttt cagaatggtc gatgtagggg gccaaaggtc agagagaaga   1980

aaatggatac actgctttga aaatgtcacc tctatcatgt ttctagtagc gcttagtgaa   2040

tatgatcaag ttctcgtgga gtcagacaat gagaaccgaa tggaggaaag caaggctctc   2100

tttagaacaa ttatcacata cccctggttc cagaactcct cggttattct gttcttaaac   2160

aagaaagatc ttctagagga gaaaatcatg tattcccatc tagtcgacta cttcccagaa   2220

tatgatggac cccagagaga tgcccaggca gcccgagaat tcattctgaa gatgttcgtg   2280

gacctgaacc cagacagtga caaaattatc tactcccact tcacgtgcgc cacagacacc   2340

gagaatatcc gctttgtctt tgctgccgtc aaggacacca tcctccagtt gaacctgaag   2400

gatattggtc tgttctaa                                                 2418


<210>  70
<211>  805
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; D2s-linker-Gqi5 G208A

<400>  70

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Pro Leu Asn Leu Ser Trp 
            20                  25                  30          


Tyr Asp Asp Asp Leu Glu Arg Gln Asn Trp Ser Arg Pro Phe Asn Gly 
        35                  40                  45              


Ser Asp Gly Lys Ala Asp Arg Pro His Tyr Asn Tyr Tyr Ala Thr Leu 
    50                  55                  60                  


Leu Thr Leu Leu Ile Ala Val Ile Val Phe Gly Asn Val Leu Val Cys 
65                  70                  75                  80  


Met Ala Val Ser Arg Glu Lys Ala Leu Gln Thr Thr Thr Asn Tyr Leu 
                85                  90                  95      


Ile Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr Leu Val Met 
            100                 105                 110         


Pro Trp Val Val Tyr Leu Glu Val Val Gly Glu Trp Lys Phe Ser Arg 
        115                 120                 125             


Ile His Cys Asp Ile Phe Val Thr Leu Asp Val Met Met Cys Thr Ala 
    130                 135                 140                 


Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg Tyr Thr Ala Val 
145                 150                 155                 160 


Ala Met Pro Met Leu Tyr Asn Thr Arg Tyr Ser Ser Lys Arg Arg Val 
                165                 170                 175     


Thr Val Met Ile Ser Ile Val Trp Val Leu Ser Phe Thr Ile Ser Cys 
            180                 185                 190         


Pro Leu Leu Phe Gly Leu Asn Asn Ala Asp Gln Asn Glu Cys Ile Ile 
        195                 200                 205             


Ala Asn Pro Ala Phe Val Val Tyr Ser Ser Ile Val Ser Phe Tyr Val 
    210                 215                 220                 


Pro Phe Ile Val Thr Leu Leu Val Tyr Ile Lys Ile Tyr Ile Val Leu 
225                 230                 235                 240 


Arg Arg Arg Arg Lys Arg Val Asn Thr Lys Arg Ser Ser Arg Ala Phe 
                245                 250                 255     


Arg Ala His Leu Arg Ala Pro Leu Lys Glu Ala Ala Arg Arg Ala Gln 
            260                 265                 270         


Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser Pro Pro Glu Arg Thr 
        275                 280                 285             


Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln Leu Thr Leu Pro Asp 
    290                 295                 300                 


Pro Ser His His Gly Leu His Ser Thr Pro Asp Ser Pro Ala Lys Pro 
305                 310                 315                 320 


Glu Lys Asn Gly His Ala Lys Asp His Pro Lys Ile Ala Lys Ile Phe 
                325                 330                 335     


Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg Thr Ser Leu Lys Thr 
            340                 345                 350         


Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu Lys Lys Ala Thr Gln 
        355                 360                 365             


Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile Cys Trp Leu Pro Phe 
    370                 375                 380                 


Phe Ile Thr His Ile Leu Asn Ile His Cys Asp Cys Asn Ile Pro Pro 
385                 390                 395                 400 


Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr Val Asn Ser Ala Val 
                405                 410                 415     


Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu Phe Arg Lys Ala Phe 
            420                 425                 430         


Leu Lys Ile Leu His Cys Phe Glu Arg Pro Ala Asp Gly Arg Met Thr 
        435                 440                 445             


Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala 
    450                 455                 460                 


Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg 
465                 470                 475                 480 


Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser 
                485                 490                 495     


Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly 
            500                 505                 510         


Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr Gln Asn 
        515                 520                 525             


Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Lys 
    530                 535                 540                 


Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg 
545                 550                 555                 560 


Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp 
                565                 570                 575     


Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp 
            580                 585                 590         


Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn 
        595                 600                 605             


Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp 
    610                 615                 620                 


Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe 
625                 630                 635                 640 


Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Ala Gln Arg 
                645                 650                 655     


Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile 
            660                 665                 670         


Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser 
        675                 680                 685             


Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile 
    690                 695                 700                 


Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn 
705                 710                 715                 720 


Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp 
                725                 730                 735     


Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg 
            740                 745                 750         


Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys 
        755                 760                 765             


Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg 
    770                 775                 780                 


Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys 
785                 790                 795                 800 


Asp Ile Gly Leu Phe 
                805 


<210>  71
<211>  2284
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct; Smyc-DOR-Gqi5

<400>  71
catgaagacg atcatcgccc tgagctacat cttctgcctg gtattcgccg aacaaaagct     60

catttccgaa gaggatcttg ccatggagct ggtgccctct gcccgtgcgg agctgcagtc    120

ctcgcccctc gtcaacctct cggacgcctt tcccagcgcc ttccccagcg cgggcgccaa    180

tgcgtcgggg tcgccgggag cccgtagtgc ctcgtccctc gccctagcca tcgccatcac    240

cgcgctctac tcggctgtgt gcgcagtggg gcttctgggc aacgtgctcg tcatgtttgg    300

catcgtccgg tacaccaaat tgaagaccgc caccaacatc tacatcttca atctggcttt    360

ggctgatgcg ctggccacca gcacgctgcc cttccagagc gccaagtact tgatggaaac    420

gtggccgttt ggcgagctgc tgtgcaaggc tgtgctctcc attgactact acaacatgtt    480

cactagcatc ttcaccctca ccatgatgag cgtggaccgc tacattgctg tctgccatcc    540

tgtcaaagcc ctggacttcc ggacaccagc caaggccaag ctgatcaata tatgcatctg    600

ggtcttggct tcaggtgtcg gggtccccat catggtcatg gcagtgaccc aaccccggga    660

tggtgcagtg gtatgcatgc tccagttccc cagtcccagc tggtactggg acactgtgac    720

caagatctgc gtgttcctct ttgccttcgt ggtgccgatc ctcatcatca cggtgtgcta    780

tggcctcatg ctactgcgcc tgcgcagcgt gcgtctgctg tccggttcca aggagaagga    840

ccgcagcctg cggcgcatca cgcgcatggt gctggtggtg gtgggcgcct tcgtggtgtg    900

ctgggcgccc atccacatct tcgtcatcgt ctggacgctg gtggacatca atcggcgcga    960

cccacttgtg gtggccgcac tgcacctgtg cattgcgctg ggctacgcca acagcagcct   1020

caacccggtt ctctacgcct tcctggacga gaacttcaag cgctgcttcc gccagctctg   1080

tcgcacgccc tgcggccgcc aagaacccgg cagtctccgt cgtccccgcc aggccaccac   1140

gcgtgagcgt gtcactgcct gcaccccctc cgacggcccg ggcggtggcg ctgccgcctt   1200

cgaaatgact ctggagtcca tcatggcgtg ctgcctgagc gaggaggcca aggaagcccg   1260

gcggatcaac gacgagatcg agcggcagct ccgcagggac aagcgggacg cccgccggga   1320

gctcaagctg ctgctgctcg ggacaggaga gagtggcaag agtacgttta tcaagcagat   1380

gagaatcatc catgggtcag gatactctga tgaagataaa aggggcttca ccaagctggt   1440

gtatcagaac atcttcacgg ccatgcaggc catgatcaga gccatggaca cactcaagat   1500

cccatacaag tatgagcaca ataaggctca tgcacaatta gttcgagaag ttgatgtgga   1560

gaaggtgtct gcttttgaga atccatatgt agatgcaata aagagtttat ggaatgatcc   1620

tggaatccag gaatgctatg atagacgacg agaatatcaa ttatctgact ctaccaaata   1680

ctatcttaat gacttggacc gcgtagctga ccctgcctac ctgcctacgc aacaagatgt   1740

gcttagagtt cgagtcccca ccacagggat catcgaatac ccctttgact tacaaagtgt   1800

cattttcaga atggtcgatg tagggggcca aaggtcagag agaagaaaat ggatacactg   1860

ctttgaaaat gtcacctcta tcatgtttct agtagcgctt agtgaatatg atcaagttct   1920

cgtggagtca gacaatgaga accgaatgga ggaaagcaag gctctcttta gaacaattat   1980

cacatacccc tggttccaga actcctcggt tattctgttc ttaaacaaga aagatcttct   2040

agaggagaaa atcatgtatt cccatctagt cgactacttc ccagaatatg atggacccca   2100

gagagatgcc caggcagccc gagaattcat tctgaagatg ttcgtggacc tgaacccaga   2160

cagtgacaaa attatctact cccacttcac gtgcgccaca gacaccgaga atatccgctt   2220

tgtctttgct gccgtcaagg acaccatcct ccagttgaac ctgaaggata ttggtctgtt   2280

ctaa                                                                2284


<210>  72
<211>  760
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct; myc-tagged DOR-Gqi5

<400>  72

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Met Glu Leu Val Pro 
            20                  25                  30          


Ser Ala Arg Ala Glu Leu Gln Ser Ser Pro Leu Val Asn Leu Ser Asp 
        35                  40                  45              


Ala Phe Pro Ser Ala Phe Pro Ser Ala Gly Ala Asn Ala Ser Gly Ser 
    50                  55                  60                  


Pro Gly Ala Arg Ser Ala Ser Ser Leu Ala Leu Ala Ile Ala Ile Thr 
65                  70                  75                  80  


Ala Leu Tyr Ser Ala Val Cys Ala Val Gly Leu Leu Gly Asn Val Leu 
                85                  90                  95      


Val Met Phe Gly Ile Val Arg Tyr Thr Lys Leu Lys Thr Ala Thr Asn 
            100                 105                 110         


Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr 
        115                 120                 125             


Leu Pro Phe Gln Ser Ala Lys Tyr Leu Met Glu Thr Trp Pro Phe Gly 
    130                 135                 140                 


Glu Leu Leu Cys Lys Ala Val Leu Ser Ile Asp Tyr Tyr Asn Met Phe 
145                 150                 155                 160 


Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala 
                165                 170                 175     


Val Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Ala Lys Ala 
            180                 185                 190         


Lys Leu Ile Asn Ile Cys Ile Trp Val Leu Ala Ser Gly Val Gly Val 
        195                 200                 205             


Pro Ile Met Val Met Ala Val Thr Gln Pro Arg Asp Gly Ala Val Val 
    210                 215                 220                 


Cys Met Leu Gln Phe Pro Ser Pro Ser Trp Tyr Trp Asp Thr Val Thr 
225                 230                 235                 240 


Lys Ile Cys Val Phe Leu Phe Ala Phe Val Val Pro Ile Leu Ile Ile 
                245                 250                 255     


Thr Val Cys Tyr Gly Leu Met Leu Leu Arg Leu Arg Ser Val Arg Leu 
            260                 265                 270         


Leu Ser Gly Ser Lys Glu Lys Asp Arg Ser Leu Arg Arg Ile Thr Arg 
        275                 280                 285             


Met Val Leu Val Val Val Gly Ala Phe Val Val Cys Trp Ala Pro Ile 
    290                 295                 300                 


His Ile Phe Val Ile Val Trp Thr Leu Val Asp Ile Asn Arg Arg Asp 
305                 310                 315                 320 


Pro Leu Val Val Ala Ala Leu His Leu Cys Ile Ala Leu Gly Tyr Ala 
                325                 330                 335     


Asn Ser Ser Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Arg Cys Phe Arg Gln Leu Cys Arg Thr Pro Cys Gly Arg Gln Glu 
        355                 360                 365             


Pro Gly Ser Leu Arg Arg Pro Arg Gln Ala Thr Thr Arg Glu Arg Val 
    370                 375                 380                 


Thr Ala Cys Thr Pro Ser Asp Gly Pro Gly Gly Gly Ala Ala Ala Phe 
385                 390                 395                 400 


Glu Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala 
                405                 410                 415     


Lys Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg 
            420                 425                 430         


Asp Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr 
        435                 440                 445             


Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His 
    450                 455                 460                 


Gly Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val 
465                 470                 475                 480 


Tyr Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp 
                485                 490                 495     


Thr Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln 
            500                 505                 510         


Leu Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro 
        515                 520                 525             


Tyr Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu 
    530                 535                 540                 


Cys Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr 
545                 550                 555                 560 


Tyr Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr 
                565                 570                 575     


Gln Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu 
            580                 585                 590         


Tyr Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly 
        595                 600                 605             


Gly Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val 
    610                 615                 620                 


Thr Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu 
625                 630                 635                 640 


Val Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe 
                645                 650                 655     


Arg Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu 
            660                 665                 670         


Phe Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His 
        675                 680                 685             


Leu Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln 
    690                 695                 700                 


Ala Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp 
705                 710                 715                 720 


Ser Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu 
                725                 730                 735     


Asn Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu 
            740                 745                 750         


Asn Leu Lys Asp Ile Gly Leu Phe 
        755                 760 


<210>  73
<211>  805
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; flag-tagged D2s-linker-Gqi5

<400>  73

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Ala Met Asp Pro Leu Asn Leu Ser Trp 
            20                  25                  30          


Tyr Asp Asp Asp Leu Glu Arg Gln Asn Trp Ser Arg Pro Phe Asn Gly 
        35                  40                  45              


Ser Asp Gly Lys Ala Asp Arg Pro His Tyr Asn Tyr Tyr Ala Thr Leu 
    50                  55                  60                  


Leu Thr Leu Leu Ile Ala Val Ile Val Phe Gly Asn Val Leu Val Cys 
65                  70                  75                  80  


Met Ala Val Ser Arg Glu Lys Ala Leu Gln Thr Thr Thr Asn Tyr Leu 
                85                  90                  95      


Ile Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr Leu Val Met 
            100                 105                 110         


Pro Trp Val Val Tyr Leu Glu Val Val Gly Glu Trp Lys Phe Ser Arg 
        115                 120                 125             


Ile His Cys Asp Ile Phe Val Thr Leu Asp Val Met Met Cys Thr Ala 
    130                 135                 140                 


Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg Tyr Thr Ala Val 
145                 150                 155                 160 


Ala Met Pro Met Leu Tyr Asn Thr Arg Tyr Ser Ser Lys Arg Arg Val 
                165                 170                 175     


Thr Val Met Ile Ser Ile Val Trp Val Leu Ser Phe Thr Ile Ser Cys 
            180                 185                 190         


Pro Leu Leu Phe Gly Leu Asn Asn Ala Asp Gln Asn Glu Cys Ile Ile 
        195                 200                 205             


Ala Asn Pro Ala Phe Val Val Tyr Ser Ser Ile Val Ser Phe Tyr Val 
    210                 215                 220                 


Pro Phe Ile Val Thr Leu Leu Val Tyr Ile Lys Ile Tyr Ile Val Leu 
225                 230                 235                 240 


Arg Arg Arg Arg Lys Arg Val Asn Thr Lys Arg Ser Ser Arg Ala Phe 
                245                 250                 255     


Arg Ala His Leu Arg Ala Pro Leu Lys Glu Ala Ala Arg Arg Ala Gln 
            260                 265                 270         


Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser Pro Pro Glu Arg Thr 
        275                 280                 285             


Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln Leu Thr Leu Pro Asp 
    290                 295                 300                 


Pro Ser His His Gly Leu His Ser Thr Pro Asp Ser Pro Ala Lys Pro 
305                 310                 315                 320 


Glu Lys Asn Gly His Ala Lys Asp His Pro Lys Ile Ala Lys Ile Phe 
                325                 330                 335     


Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg Thr Ser Leu Lys Thr 
            340                 345                 350         


Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu Lys Lys Ala Thr Gln 
        355                 360                 365             


Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile Cys Trp Leu Pro Phe 
    370                 375                 380                 


Phe Ile Thr His Ile Leu Asn Ile His Cys Asp Cys Asn Ile Pro Pro 
385                 390                 395                 400 


Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr Val Asn Ser Ala Val 
                405                 410                 415     


Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu Phe Arg Lys Ala Phe 
            420                 425                 430         


Leu Lys Ile Leu His Cys Phe Glu Arg Pro Ala Asp Gly Arg Met Thr 
        435                 440                 445             


Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys Glu Ala 
    450                 455                 460                 


Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Arg 
465                 470                 475                 480 


Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser 
                485                 490                 495     


Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly 
            500                 505                 510         


Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr Gln Asn 
        515                 520                 525             


Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Lys 
    530                 535                 540                 


Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg 
545                 550                 555                 560 


Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp 
                565                 570                 575     


Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp 
            580                 585                 590         


Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn 
        595                 600                 605             


Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp 
    610                 615                 620                 


Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe 
625                 630                 635                 640 


Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg 
                645                 650                 655     


Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile 
            660                 665                 670         


Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser 
        675                 680                 685             


Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile 
    690                 695                 700                 


Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn 
705                 710                 715                 720 


Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp 
                725                 730                 735     


Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg 
            740                 745                 750         


Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys 
        755                 760                 765             


Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg 
    770                 775                 780                 


Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys 
785                 790                 795                 800 


Asp Ile Gly Leu Phe 
                805 


<210>  74
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct; DNA encoding linker

<400>  74
ttcgaaagac ctgcagacgg taga                                            24


<210>  75
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; linker

<400>  75

Phe Glu Arg Pro Ala Asp Gly Arg 
1               5               


<210>  76
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; DRD2 human

<400>  76

His Cys Asp Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp 
1               5                   10                  15      


Leu Gly Tyr Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe 
            20                  25                  30          


Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
        35                  40                  45      


<210>  77
<211>  60
<212>  PRT
<213>  Artificial

<220>
<223>  DRD1 human

<400>  77

Cys Ile Asp Ser Asn Thr Phe Asp Val Phe Val Trp Phe Gly Trp Ala 
1               5                   10                  15      


Asn Ser Ser Leu Asn Pro Ile Ile Tyr Ala Phe Asn Ala Asp Phe Arg 
            20                  25                  30          


Lys Ala Phe Ser Thr Leu Leu Gly Cys Tyr Arg Leu Cys Pro Ala Thr 
        35                  40                  45              


Asn Asn Ala Ile Glu Thr Val Ser Ile Asn Asn Asn 
    50                  55                  60  


<210>  78
<211>  46
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic construct; DRD3 human

<400>  78

Cys Gln Thr Cys His Val Ser Pro Glu Leu Tyr Ser Ala Thr Thr Trp 
1               5                   10                  15      


Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr Thr Thr Phe 
            20                  25                  30          


Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu Ser Cys 
        35                  40                  45      


<210>  79
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; DRD4 human

<400>  79

Cys Pro Ala Cys Ser Val Pro Pro Arg Leu Val Ser Ala Val Thr Trp 
1               5                   10                  15      


Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr Thr Val Phe 
            20                  25                  30          


Asn Ala Glu Phe Arg Asn Val Phe Arg Lys Ala Leu Arg Ala Cys Cys 
        35                  40                  45              


<210>  80
<211>  64
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct; DRD5 human

<400>  80

Ala Gly Phe Pro Cys Val Ser Glu Thr Thr Phe Asp Val Phe Val Trp 
1               5                   10                  15      


Phe Gly Trp Ala Asn Ser Ser Leu Asn Pro Val Ile Tyr Ala Phe Asn 
            20                  25                  30          


Ala Asp Phe Gln Lys Val Phe Ala Gln Leu Leu Gly Cys Ser His Phe 
        35                  40                  45              


Cys Ser Arg Thr Pro Val Glu Thr Val Asn Ile Ser Asn Glu Leu Ile 
    50                  55                  60                  


<210>  81
<211>  61
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; ADA1A human

<400>  81

Phe Pro Asp Phe Lys Pro Ser Glu Thr Val Phe Lys Ile Val Phe Trp 
1               5                   10                  15      


Leu Gly Tyr Leu Asn Ser Cys Ile Asn Pro Ile Ile Tyr Pro Cys Ser 
            20                  25                  30          


Ser Gln Glu Phe Lys Lys Ala Phe Gln Asn Val Leu Arg Ile Gln Cys 
        35                  40                  45              


Leu Cys Arg Lys Gln Ser Ser Lys His Ala Leu Gly Tyr 
    50                  55                  60      


<210>  82
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct; ADA2A human

<400>  82

Cys Ser Val Pro Arg Thr Leu Phe Lys Phe Phe Phe Trp Phe Gly Tyr 
1               5                   10                  15      


Cys Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn His Asp 
            20                  25                  30          


Phe Arg Arg Ala Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys Arg 
        35                  40                  45              


Ile Val 
    50  


<210>  83
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; ADRB1 human

<400>  83

Phe His Arg Glu Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp 
1               5                   10                  15      


Leu Gly Tyr Ala Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser 
            20                  25                  30          


Pro Asp Phe Arg Lys Ala Phe Gln Arg Leu Leu Cys Cys Ala Arg Arg 
        35                  40                  45              


Ala Ala Arg Arg Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser 
    50                  55                  60                  


Gly 
65  


<210>  84
<211>  62
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; ADRB2 human

<400>  84

Ile Gln Asp Asn Leu Ile Arg Lys Glu Val Tyr Ile Leu Leu Asn Trp 
1               5                   10                  15      


Ile Gly Tyr Val Asn Ser Gly Phe Asn Pro Leu Ile Tyr Cys Arg Ser 
            20                  25                  30          


Pro Asp Phe Arg Ile Ala Phe Gln Glu Leu Leu Cys Leu Arg Arg Ser 
        35                  40                  45              


Ser Leu Lys Ala Tyr Gly Asn Gly Tyr Ser Ser Asn Gly Asn 
    50                  55                  60          


<210>  85
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct; acm4 human

<400>  85

Phe Cys Gln Ser Cys Ile Pro Asp Thr Val Trp Ser Ile Gly Tyr Trp 
1               5                   10                  15      


Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys 
            20                  25                  30          


Asn Ala Thr Phe Lys Lys Thr Phe Arg His Leu Leu Leu Cys Gln Tyr 
        35                  40                  45              


Arg Asn Ile Gly Thr Ala Arg 
    50                  55  


<210>  86
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; 5HT5A_HUMAN

<400>  86

Leu Cys Ser Cys Asp Ile Pro Ala Ile Trp Lys Ser Ile Phe Leu Trp 
1               5                   10                  15      


Leu Gly Tyr Ser Asn Ser Phe Phe Asn Pro Leu Ile Tyr Thr Ala Phe 
            20                  25                  30          


Asn Lys Asn Tyr Asn Ser Ala Phe Lys Asn Phe Phe Ser Arg Gln His 
        35                  40                  45              


<210>  87
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct; CCR5_HUMAN

<400>  87

Cys Ser Ser Ser Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr 
1               5                   10                  15      


Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val 
            20                  25                  30          


Gly Glu Lys Phe Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile 
        35                  40                  45              


Ala Lys Arg Phe Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro 
    50                  55                  60                  


Glu 
65  


<210>  88
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct; oprd human

<400>  88

Asp Arg Arg Asp Pro Leu Val Val Ala Ala Leu His Leu Cys Ile Ala 
1               5                   10                  15      


Leu Gly Tyr Ala Asn Ser Ser Leu Asn Pro Val Leu Tyr Ala Phe Leu 
            20                  25                  30          


Asp Glu Asn Phe Lys Arg Cys Phe Arg Gln Leu Cys Arg Lys Pro Cys 
        35                  40                  45              


Gly Arg Pro Asp Pro Ser Ser Phe Ser Arg Ala Arg Glu Ala Thr Ala 
    50                  55                  60                  


Arg 
65  


<210>  89
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; OPRK human

<400>  89

Thr Ser His Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala 
1               5                   10                  15      


Leu Gly Tyr Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu 
            20                  25                  30          


Asp Glu Asn Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys 
        35                  40                  45              


Met Arg Met Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln 
    50                  55                  60                  


Asp 
65  


<210>  90
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; OPRM_HUMAN

<400>  90

Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile 
1               5                   10                  15      


Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe 
            20                  25                  30          


Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Ile Pro Thr 
        35                  40                  45              


Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile Arg Gln Asn Thr 
    50                  55                  60                  


Arg 
65  


<210>  91
<211>  63
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct; OPSD human

<400>  91

His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met Thr Ile Pro Ala Phe 
1               5                   10                  15      


Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val Ile Tyr Ile Met Met 
            20                  25                  30          


Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr Ile Cys Cys Gly Lys 
        35                  40                  45              


Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr Val Ser Lys Thr 
    50                  55                  60              


<210>  92
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; CNR1 human

<400>  92

Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
1               5                   10                  15      


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
            20                  25                  30          


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
        35                  40                  45              


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
    50                  55                  60                  


His 
65  


<210>  93
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; AA2AR

<400>  93

Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu Ala Ile Val 
1               5                   10                  15      


Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr Ala Tyr Arg 
            20                  25                  30          


Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg Ser His Val 
        35                  40                  45              


Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser Ala Arg Val 
    50                  55                  60                  


Leu 
65  


<210>  94
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct; TSHR_HUMAN

<400>  94

Asn Lys Pro Leu Ile Thr Val Ser Asn Ser Lys Ile Leu Leu Val Leu 
1               5                   10                  15      


Phe Tyr Pro Leu Asn Ser Cys Ala Asn Pro Phe Leu Tyr Ala Ile Phe 
            20                  25                  30          


Thr Lys Ala Phe Gln Arg Asp Val Phe Ile Leu Leu Ser Lys Phe Gly 
        35                  40                  45              


Ile Cys Lys Arg Gln Ala Gln Ala Tyr Arg Gly Gln Arg Val Pro Pro 
    50                  55                  60                  


Lys 
65  


<210>  95
<211>  6248
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  95
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg     60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg    120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc    180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt    240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata    300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc    360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc    420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt    480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt    540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca    600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg    660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc    720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg    780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca    840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc    900

gagctcggat cgatatcatg aagacgatca tcgccctgag ctacatcttc tgcctggtat    960

tcgccgaaca aaagctcatt tccgaagagg atcttgccat ggagcccctg ttcccagcct   1020

ccacgcccag ctggaacgcc tcctccccgg gggctgcctc tggaggcggt gacaacagga   1080

cgctggtggg gccggcgccc tcggcagggg cccgggcggt gctggtgccc gtgctgtacc   1140

tgctggtgtg tgcggccggg ctgggcggga acacgctggt catctacgtg gtgctgcgct   1200

tcgccaagat gaagaccgtc accaacatct acattctcaa cctggcagtg gccgacgtcc   1260

tgtacatgct ggggctgcct ttcctggcca cgcagaacgc cgcgtccttc tggcccttcg   1320

gccccgtcct gtgccgcctg gtcatgacgc tggacggcgt caaccagttc accagtgtct   1380

tctgcctgac agtcatgagc gtggaccgct acctggcagt ggtgcacccg ctgagctcgg   1440

cccgctggcg ccgcccgcgt gtggccaagc tggcgagcgc cgcggcctgg gtcctgtctc   1500

tgtgcatgtc gctgccgctc ctggtgttcg cggacgtgca ggagggcggt acctgcaacg   1560

ccagctggcc ggagcccgtg gggctgtggg gcgccgtctt catcatctac acggccgtgc   1620

tgggcttctt cgcgccgctg ctggtcatct gcctgtgcta cctgctcatc gtggtgaagg   1680

tgagggcggc gggcgtgcgc gtgggctgcg tgcggcggcg ctcggagcgg aaggtgacgc   1740

gcatggtgtt ggtggtggtg ctggtgtttg cgggatgttg gctgcccttc ttcaccgtca   1800

acatcgtcaa cctggccgtg gcgctgcccc aggagcccgc ctccgccggc ctctacttct   1860

tcgtggtcat cctctcctac gccaacagct gtgccaaccc cgtcctctac ggcttcctct   1920

ctgacaactt ccgccagagc ttccagaagg ttctgtgcct ccgcaagggc tctggtgcca   1980

aggacgctga cgccacggag ccgcgtccag acaggatccg gcagcagcag gaggccacgc   2040

cgcccgcgca ccgcgccgca gccaacgggc ttatgcagac cagcaagctg tgagccagtg   2100

tgctggaatt aattcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctcaaa   2160

agcgggcatg acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt   2220

cacctggccc gcggtgatgc ctttgagggt ggccgcgtcc atctggtcag aaaagacaat   2280

ctttttgttg tcaagcttga ggtgtggcag gcttgagatc tggccataca cttgagtgac   2340

aatgacatcc actttgcctt tctctccaca ggtgtccact cccaggtcca actgcaggtc   2400

gagcatgcat ctagggcggc caattccgcc cctctccctc ccccccccct aacgttactg   2460

gccgaagccg cttggaataa ggccggtgtg cgtttgtcta tatgtgattt tccaccatat   2520

tgccgtcttt tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc   2580

ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag   2640

cagttcctct ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc   2700

ggaacccccc acctggcgac aggtgcctct gcggccaaaa gccacgtgta taagatacac   2760

ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca   2820

aatggctctc ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt   2880

gtatgggatc tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa   2940

aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgatgat   3000

aagcttgcca caacccacaa ggagacgacc ttccatgacc gagtacaagc ccacggtgcg   3060

cctcgccacc cgcgacgacg tcccccgggc cgtacgcacc ctcgccgccg cgttcgccga   3120

ctaccccgcc acgcgccaca ccgtcgaccc ggaccgccac atcgagcggg tcaccgagct   3180

gcaagaactc ttcctcacgc gcgtcgggct cgacatcggc aaggtgtggg tcgcggacga   3240

cggcgccgcg gtggcggtct ggaccacgcc ggagagcgtc gaagcggggg cggtgttcgc   3300

cgagatcggc ccgcgcatgg ccgagttgag cggttcccgg ctggccgcgc agcaacagat   3360

ggaaggcctc ctggcgccgc accggcccaa ggagcccgcg tggttcctgg ccaccgtcgg   3420

cgtctcgccc gaccaccagg gcaagggtct gggcagcgcc gtcgtgctcc ccggagtgga   3480

ggcggccgag cgcgccgggg tgcccgcctt cctggagacc tccgcgcccc gcaacctccc   3540

cttctacgag cggctcggct tcaccgtcac cgccgacgtc gagtgcccga aggaccgcgc   3600

gacctggtgc atgacccgca agcccggtgc ctgacgcccg ccccacgacc cgcagcgccc   3660

gaccgaaagg agcgcacgac cccatggctc cgaccgaagc cgacccgggc ggccccgccg   3720

accccgcacc cgcccccgag gcccaccgac tctagataac tgatcataat cagccatacc   3780

acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa   3840

cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa   3900

taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt   3960

ggtttgtcca aactcatcaa tgtatcttaa cgcgtcgagt gcattctagt tgtggtttgt   4020

ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg   4080

cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca   4140

acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca   4200

cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc   4260

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt   4320

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact   4380

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag   4440

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata   4500

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc   4560

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg   4620

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc   4680

tttctcaatg ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg   4740

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc   4800

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga   4860

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg   4920

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa   4980

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg   5040

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt   5100

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat   5160

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct   5220

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta   5280

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa   5340

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac   5400

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa   5460

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag   5520

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg   5580

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag   5640

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg   5700

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc   5760

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat   5820

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata   5880

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa   5940

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca   6000

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc   6060

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc   6120

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg   6180

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac   6240

ctgacgtc                                                            6248


<210>  96
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  96
atggagcccc tgttcccagc ctccacgccc agctggaacg cctcctcccc gggggctgcc     60

tctggaggcg gtgacaacag gacgctggtg gggccggcgc cctcggcagg ggcccgggcg    120

gtgctggtgc ccgtgctgta cctgctggtg tgtgcggccg ggctgggcgg gaacacgctg    180

gtcatctacg tggtgctgcg cttcgccaag atgaagaccg tcaccaacat ctacattctc    240

aacctggcag tggccgacgt cctgtacatg ctggggctgc ctttcctggc cacgcagaac    300

gccgcgtcct tctggccctt cggccccgtc ctgtgccgcc tggtcatgac gctggacggc    360

gtcaaccagt tcaccagtgt cttctgcctg acagtcatga gcgtggaccg ctacctggca    420

gtggtgcacc cgctgagctc ggcccgctgg cgccgcccgc gtgtggccaa gctggcgagc    480

gccgcggcct gggtcctgtc tctgtgcatg tcgctgccgc tcctggtgtt cgcggacgtg    540

caggagggcg gtacctgcaa cgccagctgg ccggagcccg tggggctgtg gggcgccgtc    600

ttcatcatct acacggccgt gctgggcttc ttcgcgccgc tgctggtcat ctgcctgtgc    660

tacctgctca tcgtggtgaa ggtgagggcg gcgggcgtgc gcgtgggctg cgtgcggcgg    720

cgctcggagc ggaaggtgac gcgcatggtg ttggtggtgg tgctggtgtt tgcgggatgt    780

tggctgccct tcttcaccgt caacatcgtc aacctggccg tggcgctgcc ccaggagccc    840

gcctccgccg gcctctactt cttcgtggtc atcctctcct acgccaacag ctgtgccaac    900

cccgtcctct acggcttcct ctctgacaac ttccgccaga gcttccagaa ggttctgtgc    960

ctccgcaagg gctctggtgc caaggacgct gacgccacgg agccgcgtcc agacaggatc   1020

cggcagcagc aggaggccac gccgcccgcg caccgcgccg cagccaacgg gcttatgcag   1080

accagcaagc tgtga                                                    1095


<210>  97
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Glu Pro Leu Phe Pro Ala Ser Thr Pro Ser Trp Asn Ala Ser Ser 
1               5                   10                  15      


Pro Gly Ala Ala Ser Gly Gly Gly Asp Asn Arg Thr Leu Val Gly Pro 
            20                  25                  30          


Ala Pro Ser Ala Gly Ala Arg Ala Val Leu Val Pro Val Leu Tyr Leu 
        35                  40                  45              


Leu Val Cys Ala Ala Gly Leu Gly Gly Asn Thr Leu Val Ile Tyr Val 
    50                  55                  60                  


Val Leu Arg Phe Ala Lys Met Lys Thr Val Thr Asn Ile Tyr Ile Leu 
65                  70                  75                  80  


Asn Leu Ala Val Ala Asp Val Leu Tyr Met Leu Gly Leu Pro Phe Leu 
                85                  90                  95      


Ala Thr Gln Asn Ala Ala Ser Phe Trp Pro Phe Gly Pro Val Leu Cys 
            100                 105                 110         


Arg Leu Val Met Thr Leu Asp Gly Val Asn Gln Phe Thr Ser Val Phe 
        115                 120                 125             


Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala Val Val His Pro 
    130                 135                 140                 


Leu Ser Ser Ala Arg Trp Arg Arg Pro Arg Val Ala Lys Leu Ala Ser 
145                 150                 155                 160 


Ala Ala Ala Trp Val Leu Ser Leu Cys Met Ser Leu Pro Leu Leu Val 
                165                 170                 175     


Phe Ala Asp Val Gln Glu Gly Gly Thr Cys Asn Ala Ser Trp Pro Glu 
            180                 185                 190         


Pro Val Gly Leu Trp Gly Ala Val Phe Ile Ile Tyr Thr Ala Val Leu 
        195                 200                 205             


Gly Phe Phe Ala Pro Leu Leu Val Ile Cys Leu Cys Tyr Leu Leu Ile 
    210                 215                 220                 


Val Val Lys Val Arg Ala Ala Gly Val Arg Val Gly Cys Val Arg Arg 
225                 230                 235                 240 


Arg Ser Glu Arg Lys Val Thr Arg Met Val Leu Val Val Val Leu Val 
                245                 250                 255     


Phe Ala Gly Cys Trp Leu Pro Phe Phe Thr Val Asn Ile Val Asn Leu 
            260                 265                 270         


Ala Val Ala Leu Pro Gln Glu Pro Ala Ser Ala Gly Leu Tyr Phe Phe 
        275                 280                 285             


Val Val Ile Leu Ser Tyr Ala Asn Ser Cys Ala Asn Pro Val Leu Tyr 
    290                 295                 300                 


Gly Phe Leu Ser Asp Asn Phe Arg Gln Ser Phe Gln Lys Val Leu Cys 
305                 310                 315                 320 


Leu Arg Lys Gly Ser Gly Ala Lys Asp Ala Asp Ala Thr Glu Pro Arg 
                325                 330                 335     


Pro Asp Arg Ile Arg Gln Gln Gln Glu Ala Thr 
            340                 345         


<210>  98
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  98

Leu Lys Ile Leu His Cys Phe Glu Met Thr Leu Glu Ser Ile 
1               5                   10                  


<210>  99
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  99

Leu Lys Ile Leu His Cys Phe Glu Arg Pro Ala Asp Gly Arg Met Thr 
1               5                   10                  15      


Leu Glu Ser Ile 
            20  


<210>  100
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct; siRNA for Gq/11 knockdown

<400>  100
gatgttcgtg gacctgaac                                                  19


